DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzr and fzr1b

DIOPT Version :9

Sequence 1:	NP_524852.2	Gene:	fzr / 45922	FlyBaseID:	FBgn0262699	Length:	478	Species:	Drosophila melanogaster
Sequence 2:	XP_003197866.1	Gene:	fzr1b / 100148604	ZFINID:	ZDB-GENE-131120-69	Length:	485	Species:	Danio rerio

Alignment Length:	486	Identity:	321/486 - (66%)
Similarity:	382/486 - (78%)	Gaps:	16/486 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EYEKRILKHYS----PVARNLFNNFESSTTPTSL---DRFIPCRAYNNWQTNFASINKSNDN--S 60
            :||:|:|:..:    |.......:..::.:|.|:   |||||.||.:||..||   :.:|:|  |
Zfish     4 DYERRLLRQINHQNVPEGHPTKQSNYAACSPVSVKSGDRFIPTRAGSNWSINF---HYANENCWS 65

  Fly    61 PQTSKKQRDCG-ETARDSLAYSCLLKNELLGSAIDDVKTAGEERNENAYTPAAKRSLFKYQSPTK 124
            |..:::.:|.. :|.:|::||:.||:|||||:.|:.|.....:...:........|||:|...||
Zfish    66 PNQNQRAKDASTDTGKDAVAYAALLRNELLGAGIETVPDPHTDDRRHTILTQDTHSLFRYTIHTK 130

  Fly   125 Q-DYNGE-CPYSLSPVSAKSQKLLRSPRKATRKISRIPFKVLDAPELQDDFYLNLVDWSSQNVLA 187
            : .::.| .||||||:|.||.||||||||..||||:|||||||||||||||||||||||:.|:|:
Zfish   131 RVPFDNEISPYSLSPLSNKSHKLLRSPRKPARKISKIPFKVLDAPELQDDFYLNLVDWSAGNLLS 195

  Fly   188 VGLGSCVYLWSACTSQVTRLCDLSPDANTVTSVSWNERGNTVAVGTHHGYVTVWDVAANKQINKL 252
            ||||:|||||||||||||||||||.|.::||||.|||||:.||||||.|:|.:||.|..:::..|
Zfish   196 VGLGACVYLWSACTSQVTRLCDLSVDGDSVTSVCWNERGSLVAVGTHKGFVQIWDAAGGRKLTSL 260

  Fly   253 NGHSARVGALAWNSDILSSGSRDRWIIQRDTRTPQLQSERRLAGHRQEVCGLKWSPDNQYLASGG 317
            .||||||||||||.:.||||||||.|:|||.|||. ..||||.||||||||||||||:|:|||||
Zfish   261 EGHSARVGALAWNGEQLSSGSRDRVILQRDVRTPP-PVERRLQGHRQEVCGLKWSPDHQHLASGG 324

  Fly   318 NDNRLYVWNQHSVNPVQSYTEHMAAVKAIAWSPHHHGLLASGGGTADRCIRFWNTLTGQPMQCVD 382
            |||:|.|||..|:.|||.|::|:|||||||||||.||||||||||||||:|||||||||.:|..|
Zfish   325 NDNKLLVWNSSSLLPVQQYSDHLAAVKAIAWSPHQHGLLASGGGTADRCLRFWNTLTGQALQSTD 389

  Fly   383 TGSQVCNLAWSKHSSELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLALSPDGEAIVTGA 447
            |||||||||||||::||||||||||||||||||||||||||||||||||||||:|||||||||||
Zfish   390 TGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAVSPDGEAIVTGA 454

  Fly   448 GDETLRFWNVFSKARSQKENKSVLNLFANIR 478
            |||||||||||||.|..||:|||||||..||
Zfish   455 GDETLRFWNVFSKTRCTKESKSVLNLFTRIR 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr	NP_524852.2	WD40	<174..469	CDD:225201	233/294 (79%)
		WD40	178..456	CDD:238121	220/277 (79%)
		WD40 repeat	217..254	CDD:293791	21/36 (58%)
		WD40 repeat	260..296	CDD:293791	25/35 (71%)
		WD40 repeat	301..337	CDD:293791	26/35 (74%)
		WD40 repeat	344..382	CDD:293791	32/37 (86%)
		WD40 repeat	387..425	CDD:293791	35/37 (95%)
		WD40 repeat	431..457	CDD:293791	24/25 (96%)
fzr1b	XP_003197866.1	WD40	91..482	CDD:225201	289/391 (74%)
		WD40	186..463	CDD:238121	220/277 (79%)
		WD40 repeat	225..262	CDD:293791	21/36 (58%)
		WD40 repeat	268..303	CDD:293791	25/35 (71%)
		WD40 repeat	308..343	CDD:293791	26/34 (76%)
		WD40 repeat	351..389	CDD:293791	32/37 (86%)
		WD40 repeat	394..432	CDD:293791	35/37 (95%)
		WD40 repeat	438..479	CDD:293791	35/40 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596007
Domainoid	1	1.000	216	1.000	Domainoid score	I2647
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	668	1.000	Inparanoid score	I722
OMA	1	1.010	-	-		QHG54440
OrthoDB	1	1.010	-	-		D1220675at2759
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	1	1.000	-	-		otm24609
orthoMCL	1	0.900	-	-		OOG6_101383
Panther	1	1.100	-	-	O	PTHR19918
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1507
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.810