DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ort and Gabrp

DIOPT Version :9

Sequence 1:	NP_524406.1	Gene:	ort / 45910	FlyBaseID:	FBgn0003011	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_112291.1	Gene:	Gabrp / 81658	RGDID:	620532	Length:	440	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	136/512 - (26%)
Similarity:	228/512 - (44%)	Gaps:	112/512 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LVICTICMKHYAK------GEFQQSLAITDILP----EDIKR-YDKMRPPKKEGQPTIVYFHVTV 61
            |.:..:|:...|:      .:|...::.:|.|.    |::.. |:|...|...|.|..:...:.:
  Rat     5 LYLAFVCLNLLAQRMCIQGNQFNVEVSRSDKLSLPGFENLTAGYNKFLRPNFGGDPVRIALTLDI 69

  Fly    62 MGLDSIDENSMTYVADVFFAQTWKDHRLRLPEN--MTQEYRLLEVDWLKNMWRPDSFFKNAKSVT 124
            ..:.||.|::|.|.|.::..|.|.|.||....|  .|.:.||:|.     :|.||::...:|...
  Rat    70 ASISSISESNMDYTATIYLRQRWTDPRLVFEGNKSFTLDARLVEF-----LWVPDTYIVESKKSF 129

  Fly   125 FQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQW-- 187
            ...:|:.|..:.|:.:.|:||.:::|..::|.|:.:.||.|||.||||:||..:..:|:.|.|
  Rat   130 LHEVTVGNRLIRLFSNGTVLYALRITTTVTCNMDLSKYPMDTQTCKLQLESWGYDGNDVEFSWLR 194

  Fly   188 --DPTTPLVVDENIELPQVALIRNETADCTQVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPTCMI 250
              |....|   ||:.|.|..:.:..|........|||:|.|.:.|.|:|.::|::..||:|:..:
  Rat   195 GNDSVRGL---ENLRLAQYTIQQYFTLVTVSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFL 256

  Fly   251 VIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVS-YLKAVDAFMSVCTVFVFMAL 314
            |::|||||||..|:.|||..:|||::|:::|....|::|||..: ::||:|.::.:|..|||.||
  Rat   257 VVLSWVSFWISLESVPARTCIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGAL 321

  Fly   315 MEYCLINIVLSDTPIPKPMAYPPKPVAGDGPKKEGEGAPPGGSNSTASKQQATMLPLADEKIEKI 379
            :||.:.:.          .:.....|...||.|:.|..                         .|
  Rat   322 LEYAVAHY----------SSLQQMAVKDRGPAKDSEEV-------------------------NI 351

  Fly   380 EKIFDEMTKNRRIVTTTRRVVRPPLDADG----------------PWIPRQE-SRIILTPTIAPP 427
            ..|.     |..|.:..|::....::..|                .::.|:: .|||...||..|
  Rat   352 TNII-----NSSISSFKRKISFASIEISGDNVNYSDLTMKASDKFKFVFREKIGRIIDYFTIQNP 411

  Fly   428 PPPPQPAAPEPELPKPKLTPAQERLKRAIYIDRSSRVLFPALFASLNGIYWCVFYEY 484
            .                            .:||.|::|||.:|...|..|| .:|.|
  Rat   412 S----------------------------NVDRYSKLLFPLIFMLANVFYW-AYYMY 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:273305	130/478 (27%)
		Neur_chan_LBD	38..235	CDD:280998	62/203 (31%)
		Neur_chan_memb	243..>334	CDD:280999	35/91 (38%)
Gabrp	NP_112291.1	LIC	43..437	CDD:273305	127/470 (27%)
		LGIC_ECD	60..241	CDD:355788	58/188 (31%)
		Cys-loop	159..174	CDD:349787	7/14 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810