DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ort and glrb

DIOPT Version :9

Sequence 1:	NP_524406.1	Gene:	ort / 45910	FlyBaseID:	FBgn0003011	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001072255.1	Gene:	glrb / 779708	XenbaseID:	XB-GENE-1011734	Length:	497	Species:	Xenopus tropicalis

Alignment Length:	498	Identity:	155/498 - (31%)
Similarity:	248/498 - (49%)	Gaps:	68/498 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KGEFQQSLAITDILPEDIKR----------------YDKMRPPKKEGQPTIVYFHVTVMGLDSID 68
            ||:.:|.|..:.:..||:.|                ||....|..:|.|..|..::.:....||.
Frog    31 KGKKKQYLCPSQLSAEDLARVPANSTSNILNRLLVSYDPRVRPNFKGIPVDVVVNIFINSFGSIQ 95

  Fly    69 ENSMTYVADVFFAQTWKDHRLRLPENMTQEYR---LLEVD--WLKNMWRPDSFFKNAKSVTFQTM 128
            |.:|.|..::|..|.|.|.||:||    .::|   .|.||  ..|.:|:||.||.|.|:..|..:
Frog    96 ETTMDYRVNIFLRQRWNDPRLKLP----NDFRGSDALTVDPTMFKCLWKPDLFFANEKNANFHDV 156

  Fly   129 TIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTPL 193
            |..|..:::::|..:|..::|::.|||.::..::|.|||.||:|:||..:|||||.|.|....|:
Frog   157 TQENILLFIFRDGDVLLSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPV 221

  Fly   194 VVDENIELPQVALIRN--ETADCTQVY-STGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSW 255
            .: |.|.|||..:...  |..:||:.| .||.:||:||:|||:|::.:|:...|.||.:||::||
Frog   222 QM-EKIALPQFDIKTEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSW 285

  Fly   256 VSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLI 320
            :||||.|:|:.|||.||:.|:|:|:::.......||.|||:||:|.::..|.:|.|.:|:||.::
Frog   286 LSFWINPDASAARVPLGIFSVLSLASECTTLAQELPKVSYVKAIDVWLIACLLFGFASLVEYAVV 350

  Fly   321 NIVLSDTPIPKPMAYPPKPVAGDGPKKEGEGAPPGGSNS---TASKQQATMLPLADEKIEKIEKI 382
            .::|:.   ||.:......:| ...:.||:||.....|:   |.:....:.|.:.:.:.:|:...
Frog   351 QVLLNS---PKRIEAEKAKIA-KAEQAEGKGANAAKKNTVNGTGTPIHISTLQVGENRCKKVCTS 411

  Fly   383 FDEMTKN---------RRIVTTTRRVVRPPLDADGPWIPRQESRIILTPTIAPPPPPPQPAAPEP 438
            ..::..|         |....:.......|::.:......|...       ...|||.:|..|
Frog   412 KSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKN-------NKKPPPAKPVIP-- 467

  Fly   439 ELPKPKLTPAQERLKRAIYIDRSSRVLFPALFASLNGIYWCVF 481
                       ...||   ||..||.|||..|...|.|||.|:
Frog   468 -----------SEAKR---IDLYSRALFPFCFLFFNVIYWLVY 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:273305	150/485 (31%)
		Neur_chan_LBD	38..235	CDD:280998	76/220 (35%)
		Neur_chan_memb	243..>334	CDD:280999	38/90 (42%)
glrb	NP_001072255.1	LIC	38..496	CDD:273305	151/489 (31%)
		LGIC_ECD_GlyR_beta	79..265	CDD:349811	71/190 (37%)
		Cys-loop	183..197	CDD:349811	5/13 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20224
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276914at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020