Protein Alignment ort and Gabrq

DIOPT Version :10

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_065234.1
• Gene: Gabrq / 57249
• MGIID: 1888498
• Length: 638
• Species: Mus musculus
• Alignment Length: 635
• Identity: 148/635 - (23%)
• Similarity: 234/635 - (36%)
• Gaps: 195/635 - (30%)

  Fly     5 IIILVICTICMKHYAKGEFQQSLAITDILPEDIKRYDKMRPPKKEGQPTIVYFHVTVMGLDSIDE 69
            |:.|..|..|         .....:..||...:..||....|...|.|..|...:.|..::.|.|
Mouse    44 ILDLFNCKNC---------ANEAVVQKILDRVLSTYDVRLRPNFGGAPVPVSVSIYVSSIEQISE 99

  Fly    70 NSMTYVADVFFAQTWKDHRLRLPE---NMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTMTIP 131
            .:|.|...:|..|||||.||...|   |:|.:||:.|     .:|.||.:|.|:|......:|:.
Mouse   100 INMDYTITMFLHQTWKDTRLAYYETNLNLTLDYRMHE-----KLWVPDCYFVNSKDAFVHDVTVE 159

  Fly   132 NHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTPLVVD 196
            |....|:.|.|:.|.::||...:|.::...:|.|.|.|||::||..:|.:|::..|:....:.:.
Mouse   160 NRVFQLHPDGTVRYGIRLTTTAACSLDLQKFPMDKQSCKLEVESYGYTVEDIVLSWEDDNAIHIT 224

  Fly   197 ENIELPQVALIRNETADCTQVY-STGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVSFWI 260
            :.:.:||...: ..|....:|| .||::..|.|.|.::|.:..|:...|.||.:..|:||:|||:
Mouse   225 DGLHIPQYTYL-GRTITSKEVYFYTGSYMRLIVKFQVQREVRSYLVQVYWPTVLTTILSWISFWM 288

  Fly   261 KPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLINIV-- 323
            ..:::.||||:|:||:|.|:|..:..:..||.:|.:||:|.::.||..|||::|:||..||.:
Mouse   289 NYDSSAARVTIGLTSILVLTTIDSHMRDKLPHISCIKAIDIYILVCLFFVFLSLLEYVYINYLFF 353

  Fly   324 ----------------------------------------------------------------- 323
                                                                             
Mouse   354 SQVPRRNHRRCRKPRRVVARYRYQEVVVANVQDGLINVEDRVEDRAGPLPDSPMQAHLASQESLG 418

  Fly   324 ----------------------------------LSDTP------IPK---------------PM 333
                                              |||.|      :|:               |:
Mouse   419 SLVFTSEQAQLATSESLSLLSSASSQTQLATGESLSDLPSTSEQTVPECTIHFHGFLTNDSIIPI 483

  Fly   334 AYPPKPVAGDGPKKE-----GEGAPPGGSNSTASKQQATM--LPLADEKIEKIEKI--------- 382
            ....:..|.|....|     .|....|.|::...|.|.:.  :..|...::|||.:
Mouse   484 KIHSRSDACDDEDSEESLSSEESHGHGSSHTGRLKLQISQRCVQEASWDLDKIEILQDDISITSS 548

  Fly   383 ---FDEMTKNRRIVTTTRRVVRPPLDADGPWIPRQESRIILTPTIAPPPPPPQPAAPEP------ 438
               .||..|.               |||..|....|..:.............:..:|.|
Mouse   549 WLGLDEQCKG---------------DADSIWSLTDEELMACDQEKDSSSESEENCSPSPGCSFNE 598

  Fly   439 ----ELPKPKLTPAQERLKRAIYIDRSSRVLFPALFASLNGIYWCVFYEY 484
                :|.||...|.         :||.||.|||..|...|.:|| :::.|
Mouse   599 GFSFQLFKPNRVPK---------VDRWSRFLFPLSFGLFNVVYW-LYHVY 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:455710	143/604 (24%)
		LGIC_ECD_HisCl	51..235	CDD:349793	57/187 (30%)
		Cys-loop	155..169	CDD:349793	4/13 (31%)
Gabrq	NP_065234.1	LGIC_ECD_GABAAR_theta	82..263	CDD:349804	57/186 (31%)
		Cys-loop	183..197	CDD:349804	4/13 (31%)
		LGIC_TM_GABAAR_theta	266..365	CDD:349858	36/98 (37%)
		TM1 helix	266..289	CDD:349858	10/22 (45%)
		TM2 helix	293..317	CDD:349858	10/23 (43%)
		TM3 helix	325..351	CDD:349858	13/25 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	491..515		6/23 (26%)
		LGIC_TM	<604..636	CDD:476813	15/41 (37%)
		TM4 helix	612..633	CDD:349858	9/29 (31%)