Protein Alignment ort and nAChRbeta2

DIOPT Version :10

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Alignment Length: 515
• Identity: 86/515 - (16%)
• Similarity: 177/515 - (34%)
• Gaps: 153/515 - (29%)

  Fly    34 PEDIKRYDKM--------RPPKKEGQPTIVYFHVTVMGLDSIDENSMTYVADVFFAQTWKDHRLR 90
            |:..:.||.:        ||.....:...|:..:.:..|..::..:.....:::..|.|.|::||
  Fly    28 PDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLR 92

  Fly    91 LPENMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTMTIPNHYMW-----LYK----DKTILYM 146
                                |.|:.:      ...:.:.:|:.::|     ||.    :..:..|
  Fly    93 --------------------WDPEEY------GGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLM 131

  Fly   147 VKLTLKL--------------SCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTP--LVV 195
            .|.|||.              ||.||...:|:|.|.|.::..|.::....:..:.....|  .:|
  Fly   132 TKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLV 196

  Fly   196 DENIELPQVALIRNETADCTQVYSTGN----------FTCLEVVFTLKRRLVYYVFNTYIPTCMI 250
            ...|:|.:..|  :...|..:|.:|.|          |:.:....|::|:.::|..|..:|...:
  Fly   197 QVGIDLTEFYL--SVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVAL 259

  Fly   251 VIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSY-LKAVDAFMSVCTVFVFMAL 314
            ..::.:.|:: |..:..:|||.::.|::|:.........:||.|. :..:..::....:.|.:::
  Fly   260 TFLTVLVFYL-PSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSV 323

  Fly   315 -MEYCLINIVLSD------TPIPKP--MAYPPK------------------PVAG---------- 342
             ...|::||....      :|:.:.  :.:.||                  |..|
  Fly   324 WTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDSTPSNGYTNEIDVRDS 388

  Fly   343 --DGP---KKEGEGAPPGGSNSTASKQQATMLPLADEKIEKIEKI------FDEMTKNRRIVTTT 396
              |.|   |...:||...|..::..........|..|.::.:..:      ..:..|:..||...
  Fly   389 ISDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDW 453

  Fly   397 RRV--------------------------------VRPPLDADGPWIPRQESRIILTPTI 424
            :.|                                .|.|:|.....||.:::..:|.|.|
  Fly   454 KFVSMVLDRFFLWLFTLSCVFGTLAIICQSPSLYDTRSPIDRQLSEIPLRKNNFMLPPDI 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:455710	86/515 (17%)
		LGIC_ECD_HisCl	51..235	CDD:349793	38/218 (17%)
		Cys-loop	155..169	CDD:349793	6/13 (46%)
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	78/479 (16%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	43/245 (18%)
		Cys-loop	154..168	CDD:349832	6/13 (46%)