Protein Alignment ort and HisCl1

DIOPT Version :10

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_731632.1
• Gene: HisCl1 / 41426
• FlyBaseID: FBgn0037950
• Length: 426
• Species: Drosophila melanogaster
• Alignment Length: 469
• Identity: 226/469 - (48%)
• Similarity: 287/469 - (61%)
• Gaps: 92/469 - (19%)

  Fly    15 MKHYAKGEFQQSLAITDILPEDIKRYDKMRPPKKEGQPTIVYFHVTVMGLDSIDENSMTYVADVF 79
            :.||     :.||::.||||...|.|||.|.||..||||:|||||||:.||||:|.|||||.|:|
  Fly    47 VSHY-----ESSLSLPDILPIPSKTYDKNRAPKLLGQPTVVYFHVTVLSLDSINEESMTYVTDIF 106

  Fly    80 FAQTWKDHRLRLPENMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTMTIPNHYMWLYKDKTIL 144
            .||:|:|.||||||||:::||:|:||||.::||||.||||||.|||..|:|||||:|||.|||:|
  Fly   107 LAQSWRDPRLRLPENMSEQYRILDVDWLHSIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLL 171

  Fly   145 YMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTPLVVDENIELPQVALIRN 209
            ||.||||.|||.|.|..||||||.|.:.:||||||.:||:|.|:.|.||||:..|||||:.:..|
  Fly   172 YMSKLTLVLSCAMKFESYPHDTQICSMMIESLSHTVEDLVFIWNMTDPLVVNTEIELPQLDISNN 236

  Fly   210 ETADCTQVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVSFWIKPEAAPARVTLGVT 274
            .|.|||..|||||||||.:||.|:|||.|::|:||||:.:||:|||:||||||||.|||||||||
  Fly   237 YTTDCTIEYSTGNFTCLAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVT 301

  Fly   275 SLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLINIVLSDTPIPKPMAYPPKP 339
            |||||:||:.:||.|||||||:||:|.:||.|:||||::|||:.::|..:
  Fly   302 SLLTLATQNTQSQQSLPPVSYVKAIDVWMSSCSVFVFLSLMEFAVVNNFM--------------- 351

  Fly   340 VAGDGPKKEGEGAPPGGSNSTASKQQATMLPLADEKIEKIEKIFDEMTKNRRIVTTTRRVVRPPL 404
                ||              .|:|   .|...:||.|..::.:...:..:|      ..::.|..
  Fly   352 ----GP--------------VATK---AMKGYSDENISDLDDLKSALQHHR------ESIIEPQY 389

  Fly   405 D--ADGPWIPRQESRIILTPTIAPPPPPPQPAAPEPELPKPKLTPAQERLKRAIYIDRSSRVLFP 467
            |  ..|.                                           ..|||||:.||..||
  Fly   390 DTFCHGH-------------------------------------------ATAIYIDKFSRFFFP 411

  Fly   468 ALFASLNGIYWCVF 481
            ..|..||.:||..|
  Fly   412 FSFFILNIVYWTTF 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:455710	221/451 (49%)
		LGIC_ECD_HisCl	51..235	CDD:349793	122/183 (67%)
		Cys-loop	155..169	CDD:349793	9/13 (69%)
HisCl1	NP_731632.1	LGIC_ECD_HisCl	78..262	CDD:349793	122/183 (67%)
		Cys-loop	182..196	CDD:349793	9/13 (69%)
		LGIC_TM_anion	265..>351	CDD:349851	58/85 (68%)
		TM1 helix	265..288	CDD:349851	14/22 (64%)
		TM2 helix	292..316	CDD:349851	18/23 (78%)
		TM3 helix	324..350	CDD:349851	14/25 (56%)