Protein Alignment ort and nAChRbeta1

DIOPT Version :10

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Alignment Length: 506
• Identity: 95/506 - (18%)
• Similarity: 180/506 - (35%)
• Gaps: 154/506 - (30%)

  Fly     1 MVFQIIILVICTICMKHYAKGEFQQSLAITDILPEDIKRYDKM-RPPKKEGQPTIVYFHVTVMGL 64
            ::..|::||..::    .:..|.::.| :.|:    .:.|:|: ||.:...|...|.|.:..:.|
  Fly     9 LLCSILVLVAFSL----VSASEDEERL-VRDL----FRGYNKLIRPVQNMTQKVGVRFGLAFVQL 64

  Fly    65 DSIDENSMTYVADVFFAQTWKDHRLRLPENMTQEYRLLEVDWL--KNMWRPD-SFFKNAKSVTFQ 126
            .:::|.:....::|:....|.|::|:..|   .:|..:.|..|  ..:|:|| ..|.||
  Fly    65 INVNEKNQIMKSNVWLRLVWYDYQLQWDE---ADYGGIGVLRLPPDKVWKPDIVLFNNA------ 120

  Fly   127 TMTIPNHYMWLYKDKTILYMVKLTL-------KLSCIMNFAIYPHDTQECKLQMESLSHTTDDLI 184
                ..:|...||...::|.....|       :.||.::...:|.|.|.|.::..|.:...|.:
  Fly   121 ----DGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQV- 180

  Fly   185 FQWDPTTPLVVDENIELPQVALIRNET-ADCTQVYSTGNFTCLEV-------------------- 228
                              .:||..|:. .|.:..:.:|.:..:||
  Fly   181 ------------------SLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYEGDSNHPTETDIT 227

  Fly   229 -VFTLKRRLVYYVFNTYIPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPP 292
             ...::|:.::|..|..:||.:|..:..:.|:: |..|..:||||::.||:|..........|||
  Fly   228 FYIIIRRKTLFYTVNLILPTVLISFLCVLVFYL-PAEAGEKVTLGISILLSLVVFLLLVSKILPP 291

  Fly   293 VS------------------------------------------YLKAVDAFMSVCTVFVFMA-- 313
            .|                                          |::::  |:.....|:||.
  Fly   292 TSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSI--FLHYLPAFLFMKRP 354

  Fly   314 -------LMEYCLINIVLSDTPIPKPMAYPPKPVAGDGPKKE----------------------- 348
                   :||...:::.....|.....|..||.::..|.|:.
  Fly   355 RKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVMELSDLHHPNCKINRKVNS 419

  Fly   349 -GE-GAPPGGSNSTASKQQATMLPLADEKIEKIEKIFDEMTKNRRIVTTTR 397
             || |...|....:.|.....:.|.|.:..|.:|.|.:.: :|..:...||
  Fly   420 GGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHL-RNEDLYIQTR 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:455710	90/476 (19%)
		LGIC_ECD_HisCl	51..235	CDD:349793	39/215 (18%)
		Cys-loop	155..169	CDD:349793	4/13 (31%)
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	95/506 (19%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	46/245 (19%)
		Cys-loop	152..166	CDD:349833	4/13 (31%)