Protein Alignment ort and lgc-38

DIOPT Version :10

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_001355511.1
• Gene: lgc-38 / 3565717
• WormBaseID: WBGene00017389
• Length: 479
• Species: Caenorhabditis elegans
• Alignment Length: 482
• Identity: 142/482 - (29%)
• Similarity: 228/482 - (47%)
• Gaps: 68/482 - (14%)

  Fly    21 GEFQQSLA--ITDILPEDIKRYDKMRPPKKEGQPTIVYFHVTVMGLDSIDENSMTYVADVFFAQT 83
            ||..::|.  :|.:|.:.|..:|:...|...|.|..|.....|..:.::.|.||.|..|::..|.
 Worm    42 GESNENLENNVTRLLDKLIASHDRRIRPNYGGPPIEVNITAHVTTISAVSEVSMDYTLDLYLRQI 106

  Fly    84 WKDHRLRLPENMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTMTIPNHYMWLYKDKTILYMVK 148
            |||.||.. |:..::...:.:|.:|.:|.||:||.|.|...|...|..|.::.:.....:|..::
 Worm   107 WKDPRLAW-ESDVEDSLTIGIDMVKTIWTPDTFFPNEKKSFFHEATSHNSFLRIDNHGNVLRSIR 170

  Fly   149 LTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTPLVVDENIELPQVALIRNETAD 213
            ||:..:|.|:...:|.|.|||.|::||..::|.|:|:.|..|..:.:|||:.|....:..::..:
 Worm   171 LTVTANCPMSLHTFPLDRQECALEVESYGYSTKDIIYHWHGTNAVTIDENVHLAHFTIGEHKHIE 235

  Fly   214 CTQVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLT 278
            .|...||||::.|...|..||.:.:|:...|.|:.:||::||||||:..||..|||.:|||::||
 Worm   236 RTISLSTGNYSRLTAYFLFKRNIGFYLIQIYFPSSLIVVISWVSFWLNREAVQARVAIGVTTVLT 300

  Fly   279 LSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLINIVLS---DTPIPKPMAY----- 335
            ::|....:.:|||.|||:|::|.|:.||...||.:|:||..|..::.   ..|...|:.|
 Worm   301 MTTLMTSTNASLPKVSYVKSLDVFLGVCFFIVFASLLEYAAIGYLMKRNRSVPAASPVQYYETEE 365

  Fly   336 ------PPKPVAG-----DGPKKEGEGAPPGGSNSTASKQQATMLPLADEKIEKIEKIFDEMTKN 389
                  .||.|.|     ||..|.     ......:.:::.::|....:..|..
 Worm   366 FFEIQCHPKFVRGAINYCDGVLKR-----EASRKKSRNRRDSSMKNYQNNNIHH----------- 414

  Fly   390 RRIVTTTRRVVRPPLDADGPWIPRQESRIILTPTIAPPPPPPQPAAPEPELPKPKLTPAQERLKR 454
                       ||   :||    ..:.||   |.::..|.||.|..|: .....|:.|||
 Worm   415 -----------RP---SDG----HVDQRI---PLLSMVPMPPIPFKPQ-NGAWGKVRPAQ----- 452

  Fly   455 AIYIDRSSRVLFPALFASLNGIYWCVF 481
               :|..||..||..|...:.:||..:
 Worm   453 ---VDLFSRFAFPIFFVIFHIVYWTYY 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:455710	138/468 (29%)
		LGIC_ECD_HisCl	51..235	CDD:349793	57/183 (31%)
		Cys-loop	155..169	CDD:349793	5/13 (38%)
lgc-38	NP_001355511.1	LIC	42..476	CDD:455710	142/480 (30%)
		LGIC_ECD_GABAR_RDL-like	76..257	CDD:349809	56/181 (31%)
		Cys-loop	177..191	CDD:349809	5/13 (38%)