Protein Alignment ort and lgc-36

DIOPT Version :10

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_001023766.1
• Gene: lgc-36 / 3565335
• WormBaseID: WBGene00008551
• Length: 536
• Species: Caenorhabditis elegans
• Alignment Length: 537
• Identity: 124/537 - (23%)
• Similarity: 222/537 - (41%)
• Gaps: 128/537 - (23%)

  Fly     1 MVFQIIILVICTIC----------MKHYAKGEF----------QQSLA--ITDILPEDIKRYDK- 42
            ::...|..:|.::|          :|..:.|.|          ::.:|  :|.:|...:|.||:
 Worm    12 LIIFFISTIILSVCGNELKFTIENVKFRSPGSFRIKRTVHPKREKGVAQNVTHLLNNVLKNYDQH 76

  Fly    43 MRPPKKEGQPTIVYFHVTVMGLDSIDENSMTYVADVFFAQTWKDHRLRLPENMTQEYRLLEVD-- 105
            .||....|:||.||..:.:..:..:.:...||..:.:|.|.|.|.||.. .|....:|.|.:.
 Worm    77 FRPGFNSGKPTKVYIDLFIRTMGPVSDLFNTYSFNCYFRQKWTDDRLHF-NNSGIGFRQLSLSMA 140

  Fly   106 WLKNMWRPDSFFKNAKSVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECK 170
            .|..:|:||::|.|........:|..|..:.|..|.||||..::|:|..|.|:.:.||.|.|.|:
 Worm   141 MLDKIWKPDTYFWNGAGSYVHGITTSNRLVRLEPDGTILYSSRITVKAKCQMDMSRYPLDKQACR 205

  Fly   171 LQMESLSHTTDDLIFQWDPTTPLVVDEN---------IELPQVALIRNETADCTQVYSTGNFT-- 224
            |.:.|.::::|::.::|    .::.|:|         .:|||.:|      ...:||...|.|
 Worm   206 LVIGSYAYSSDEVQYKW----RIMGDDNGVKIDYESIADLPQFSL------SGFKVYKPANITRD 260

  Fly   225 ----CLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAK 285
                .|||.|...|...|::.|.|:|..::|::.||:|:.|.||...|:.:|:|::||:......
 Worm   261 KEYSALEVRFYFDRHFGYFLMNFYVPCALVVLLCWVAFFTKREATAERIGIGITNVLTIVLISMD 325

  Fly   286 SQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLINIVLSDTPIPKPMAYPPKPVAGDGPKKEGE 350
            |:|..|.|....|::.|:.:|.:...:.::|:.:::             |..|...||...:|.|
 Worm   326 SKSDSPKVDSPTALEVFIWICYLTHLICMVEFTVVH-------------YHTKYNTGDPEIQEVE 377

  Fly   351 GAPPGGSNSTASKQQATMLPLADEKIEKIEKIFDEMTKNRRIVTTTRR--------VVRPPLDAD 407
                                  .|::.:|.|...:.|.||....|.||        :.||
 Worm   378 ----------------------RERLRQIIKQIPKNTNNRATEPTFRRRNAALPVSIARP----- 415

  Fly   408 GPWIPRQESRIILTPTIAPPPPPPQPAAPEPELPKPKLTPAQERLKRAIYIDRSSRVLFPALFAS 472
               :|.:..|.:                   .:.:||.:...|.::....|..........:.:|
 Worm   416 ---LPNKTKRFM-------------------SVRQPKKSEQTESIQLMRKISNMESTTHNEVESS 458

  Fly   473 LN-------GIYWCVFY 482
            ||       .:.|.::|
 Worm   459 LNLESIRQENVGWRLYY 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:455710	115/482 (24%)
		LGIC_ECD_HisCl	51..235	CDD:349793	56/200 (28%)
		Cys-loop	155..169	CDD:349793	6/13 (46%)
lgc-36	NP_001023766.1	LIC	48..520	CDD:455710	118/501 (24%)
		LGIC_ECD_GABAR_GRD-like	86..275	CDD:349808	56/199 (28%)
		Cys-loop	190..204	CDD:349808	6/13 (46%)