DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ort and Gabrg2

DIOPT Version :9

Sequence 1:	NP_524406.1	Gene:	ort / 45910	FlyBaseID:	FBgn0003011	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001380704.1	Gene:	Gabrg2 / 29709	RGDID:	61966	Length:	474	Species:	Rattus norvegicus

Alignment Length:	484	Identity:	138/484 - (28%)
Similarity:	222/484 - (45%)	Gaps:	101/484 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ITDILPEDIKRYDKMRPPKKEGQPTIVYFHVTVMGLDSIDENSMTYVADVFFAQTWKDHRLRLPE 93
            :|.||...::.||....|....:||:::..:.|..:..::..:|.|..|:||||||.|.||:.
  Rat    65 VTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKF-- 127

  Fly    94 NMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIMN 158
            |.|.:...|..:.:..:|.||:||:|:|......:|.||..:.::.|..:||.::||:...|.:.
  Rat   128 NSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQ 192

  Fly   159 FAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTPLVVD-ENIELPQVALI--RNETADCTQVYST 220
            ...:|.|...|.|:..|..:..:::::||..::..|.| .:..|.|.:.:  ||    .|:|..|
  Rat   193 LHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRN----TTEVVKT 253

  Fly   221 --GNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQH 283
              |::..:.|.|.|.||:.|:...||||..:||::|||||||..:|.|||.:||:|::||::|..
  Rat   254 TSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLS 318

  Fly   284 AKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLINIVLSDTPIPKPMAYPPKPVAGDGPKKE 348
            ..::.|||.|||:.|:|.|:|||.:|||.||:||..::..:|:.          ||......||:
  Rat   319 TIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNR----------KPSKDKDKKKK 373

  Fly   349 GE-------GAP-----PGGSNSTASKQQATMLPLADEK--IEKIEK--------IFDEMTKNRR 391
            ..       .||     |  .::|.....||.|...||:  .|.::.        .|::.
  Rat   374 NPLLRMFSFKAPTIDIRP--RSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDC----- 431

  Fly   392 IVTTTRRVVRPPLDADGPWIPRQESRIILTPTIAPPPPPPQPAAPEPELPKPKLTPAQERLKRAI 456
                          ..|.|   :..||.:                                 |..
  Rat   432 --------------RTGAW---RHGRIHI---------------------------------RIA 446

  Fly   457 YIDRSSRVLFPALFASLNGIYWCVFYEYL 485
            .:|..:|:.||..|...|.:|| |.|.||
  Rat   447 KMDSYARIFFPTAFCLFNLVYW-VSYLYL 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:273305	133/476 (28%)
		Neur_chan_LBD	38..235	CDD:280998	57/201 (28%)
		Neur_chan_memb	243..>334	CDD:280999	43/90 (48%)
Gabrg2	NP_001380704.1	LIC	68..471	CDD:273305	134/476 (28%)
Gabrg2	NP_001380704.1	LGIC_ECD_GABAAR_G	89..270	CDD:349801	53/186 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810