Protein Alignment ort and Gabra5

DIOPT Version :10

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_058991.2
• Gene: Gabra5 / 29707
• RGDID: 61859
• Length: 464
• Species: Rattus norvegicus
• Alignment Length: 508
• Identity: 147/508 - (28%)
• Similarity: 229/508 - (45%)
• Gaps: 95/508 - (18%)

  Fly     1 MVFQIIILVICTICMKHY---------AKGEFQQSLAI-TDILPEDIKRYD-KMRPPKKEGQPTI 54
            |...:::..|......|:         .:.|...::.| |.||...:..|| ::||...| :.|.
  Rat    11 MTKTLLVFCISMTLSSHFGFSQMPTSSVQDETNDNITIFTRILDGLLDGYDNRLRPGLGE-RITQ 74

  Fly    55 VYFHVTVMGLDSIDENSMTYVADVFFAQTWKDHRL-------RLPENMTQEYRLLEVDWLKNMWR 112
            |...:.|.....:.:..|.|..||||.|:|||.||       |||.|     .||    ...:|.
  Rat    75 VRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLN-----NLL----ASKIWT 130

  Fly   113 PDSFFKNAKSVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLS 177
            ||:||.|.|......||.||..:.|..|.|:||.::||:...|.|....:|.|...|.|:..|.:
  Rat   131 PDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYA 195

  Fly   178 HTTDDLIFQW---DPTTPLVVDENIELPQVALIRNETADCTQVYSTGNFTCLEVVFTLKRRLVYY 239
            :...::::.|   ...:.:|.::...|.|..|:...........|||.:|.:...|.|||::.|:
  Rat   196 YPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYF 260

  Fly   240 VFNTYIPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMS 304
            |..||:|..|.||:|.||||:..|:.|||...|||::||::|....:::|||.|:|..|:|.|::
  Rat   261 VIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIA 325

  Fly   305 VCTVFVFMALMEYCLINIVLSDTPIPKPMAYPPKPVAGDGPKKEGEGAPPGGSNSTASKQQATML 369
            ||..|||.||:|:..:|.            :..:..|.|| ||..|.|
  Rat   326 VCYAFVFSALIEFATVNY------------FTKRGWAWDG-KKALEAA----------------- 360

  Fly   370 PLADEKIEKIEKIFDEMTKNRRI-VTTTRRVVRPPLDADGPWIPRQE-----SRIILTPTIAPPP 428
                 ||:|.|:   |:..|:.. ..||.::..||.      ||:::     ...:.|.:|.
  Rat   361 -----KIKKKER---ELILNKSTNAFTTGKLTHPPN------IPKEQLPGGTGNAVGTASIR--- 408

  Fly   429 PPPQPAAPEPELPKPKLTPAQERLKRAIYIDRSSRVLFPALFASLNGIYWCVF 481
                 |:.|      |.:.:::.......||:.||::||.||.:.|.:||..:
  Rat   409 -----ASEE------KTSESKKTYNSISKIDKMSRIVFPILFGTFNLVYWATY 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:455710	141/466 (30%)
		LGIC_ECD_HisCl	51..235	CDD:349793	58/193 (30%)
		Cys-loop	155..169	CDD:349793	4/13 (31%)
Gabra5	NP_058991.2	LIC	15..450	CDD:455710	146/502 (29%)
		LGIC_ECD_GABAAR_A5	58..256	CDD:349839	63/207 (30%)
		Cys-loop	173..187	CDD:349839	4/13 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	382..414		8/51 (16%)