Protein Alignment ort and Gabrd

DIOPT Version :10

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_058985.1
• Gene: Gabrd / 29689
• RGDID: 61901
• Length: 449
• Species: Rattus norvegicus
• Alignment Length: 528
• Identity: 143/528 - (27%)
• Similarity: 219/528 - (41%)
• Gaps: 144/528 - (27%)

  Fly     7 ILVICTICMKHYAK------GEFQQSLAITDILPE-D--IKRYDKMRPPKKEGQPTIVYFHVTVM 62
            :|::||  ..|:..      |::..|......||. |  ::.|.:...|...|.|..|...:.|.
  Rat    11 LLLLCT--QPHHGARAMNDIGDYVGSNLEISWLPNLDGLMEGYARNFRPGIGGPPVNVALALEVA 73

  Fly    63 GLDSIDENSMTYVADVFFAQTWKDHRLRLPENMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQT 127
            .:|.|.|.:|.|...||..|:|:|.||..  |.|.|...|:..::..:|.||:|..||||..|..
  Rat    74 SIDHISEANMEYTMTVFLHQSWRDSRLSY--NHTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHD 136

  Fly   128 MTIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTP 192
            :|:.|..:.|..|..|||.:::|..::|.|:.|.||.|.|||.|.:||..::::|:::.|.....
  Rat   137 VTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSENQE 201

  Fly   193 LVVD-ENIELPQVALIRNE-TADCTQVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSW 255
            .:.. :.::|.|..:.... |.:.....|.|.|..|.:.|.|:|....|:..:|:|:.::|.|||
  Rat   202 QIHGLDRLQLAQFTITSYRFTTELMNFKSAGQFPRLSLHFQLRRNRGVYIIQSYMPSVLLVAMSW 266

  Fly   256 VSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLI 320
            |||||...|.||||:||:|::||::|....::||||..|.:||:|.:..:|.||||.||:||...
  Rat   267 VSFWISQAAVPARVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFA 331

  Fly   321 N---------------------------IVL---------SDTPIPKPMAYPPKPVAGD------ 343
            :                           |||         .:..|.:.....|..:.|.
  Rat   332 HFNADYRKKRKAKVKVTKPRAEMDVRNAIVLFSLSAAGVSQELAISRRQGRVPGNLMGSYRSVEV 396

  Fly   344 GPKKEGEGAPPGGSNSTASKQQATMLPLADEKIEKIEKIFDEMTKNRRIVTTTRRVVRPPLDADG 408
            ..|||| |:.|||.....|:.:                                     |:|||
  Rat   397 EAKKEG-GSRPGGPGGIRSRLK-------------------------------------PIDAD- 422

  Fly   409 PWIPRQESRIILTPTIAPPPPPPQPAAPEPELPKPKLTPAQERLKRAIYIDRSSRVLFPALFASL 473
                                                            .||..:|.:|||.||::
  Rat   423 ------------------------------------------------TIDIYARAVFPAAFAAV 439

  Fly   474 NGIYWCVF 481
            |.|||..:
  Rat   440 NIIYWAAY 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:455710	137/496 (28%)
		LGIC_ECD_HisCl	51..235	CDD:349793	59/185 (32%)
		Cys-loop	155..169	CDD:349793	7/13 (54%)
Gabrd	NP_058985.1	LGIC_ECD	63..246	CDD:475126	59/184 (32%)
		LGIC_TM	249..>337	CDD:476813	40/87 (46%)
		TM1 helix	252..272	CDD:349850	10/19 (53%)
		TM2 helix	281..302	CDD:349850	8/20 (40%)
		TM3 helix	312..334	CDD:349850	9/21 (43%)