Protein Alignment ort and GLRB

DIOPT Version :10

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_000815.1
• Gene: GLRB / 2743
• HGNCID: 4329
• Length: 497
• Species: Homo sapiens
• Alignment Length: 499
• Identity: 156/499 - (31%)
• Similarity: 249/499 - (49%)
• Gaps: 70/499 - (14%)

  Fly    20 KGEFQQSLAITDILPEDIKR----------------YDKMRPPKKEGQPTIVYFHVTVMGLDSID 68
            ||:.:|.|..:....||:.|                ||....|..:|.|..|..::.:....||.
Human    31 KGKKKQYLCPSQQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQ 95

  Fly    69 ENSMTYVADVFFAQTWKDHRLRLPENMTQEYR---LLEVD--WLKNMWRPDSFFKNAKSVTFQTM 128
            |.:|.|..::|..|.|.|.||:||    .::|   .|.||  ..|.:|:||.||.|.||..|..:
Human    96 ETTMDYRVNIFLRQKWNDPRLKLP----SDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDV 156

  Fly   129 TIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTPL 193
            |..|..:::::|..:|..::|::.|||.::..::|.|||.||:|:||..:|||||.|.|....|:
Human   157 TQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPV 221

  Fly   194 VVDENIELPQVALIRN--ETADCTQVY-STGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSW 255
            .: |.|.|||..:.:.  |..:||:.| .||.:||:||:|||:|::.:|:...|.||.:||::||
Human   222 QL-EKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSW 285

  Fly   256 VSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLI 320
            :||||.|:|:.|||.||:.|:|:|:::.....:.||.|||:||:|.::..|.:|.|.:|:||.::
Human   286 LSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVV 350

  Fly   321 NIVLSDTPIPKPM----AYPPKPVAGDGPKKEGEGAPPGGSNSTASKQQATMLPLADEKIEKIEK 381
            .::|::   ||.:    |...|....||  |.|..|.....|.|.:....:.|.:.:.:.:|:..
Human   351 QVMLNN---PKRVEAEKARIAKAEQADG--KGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCT 410

  Fly   382 IFDEMTKN---------RRIVTTTRRVVRPPLDADGPWIPRQESRIILTPTIAPPPPPPQPAAPE 437
            ...::..|         |....:.......|::.:......|...       ...|||.:|..|
Human   411 SKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKN-------NKKPPPAKPVIP- 467

  Fly   438 PELPKPKLTPAQERLKRAIYIDRSSRVLFPALFASLNGIYWCVF 481
                    |.|:.       ||..:|.|||..|...|.|||.::
Human   468 --------TAAKR-------IDLYARALFPFCFLFFNVIYWSIY 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:455710	152/486 (31%)
		LGIC_ECD_HisCl	51..235	CDD:349793	72/191 (38%)
		Cys-loop	155..169	CDD:349793	5/13 (38%)
GLRB	NP_000815.1	LIC	43..496	CDD:455710	152/485 (31%)
		LGIC_ECD_GlyR_beta	79..265	CDD:349811	72/190 (38%)
		Cys-loop	183..197	CDD:349811	5/13 (38%)