DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ort and lgc-43

DIOPT Version :9

Sequence 1:	NP_524406.1	Gene:	ort / 45910	FlyBaseID:	FBgn0003011	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001023062.1	Gene:	lgc-43 / 259591	WormBaseID:	WBGene00008076	Length:	679	Species:	Caenorhabditis elegans

Alignment Length:	253	Identity:	72/253 - (28%)
Similarity:	135/253 - (53%)	Gaps:	5/253 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 LDSIDENSMTYVADVFFAQTWKDHRLRLPENMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTM 128
            |.:.|...|.:..||....:|.|  :||..|.|:..|:.|...::.:||||.:..|:|...|..:
Worm   355 LANFDSEMMEFSMDVEMEFSWID--IRLVNNYTKPIRIREKPIIEQIWRPDPYIVNSKHSYFHYV 417

  Fly   129 TIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTPL 193
            :.||..|.:..:..:.|.|:::...||.|:|.:||||.|||.|::.|::::...:.|.|. :.|:
Worm   418 SFPNIRMRITPEGLVTYTVRVSSVCSCFMSFCLYPHDRQECDLRISSIAYSNQYVKFHWH-SNPI 481

  Fly   194 VVDENIELPQVALIRNETADCTQVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVSF 258
            .....|.||::.:.:.:||:|:......:.:||.::|:|:|....:|...|:|:.:.::.:||:.
Worm   482 KFQSKITLPELHITKIKTAECSTKGKLVDASCLRIIFSLERDSARFVIEKYVPSTLAMMFAWVAP 546

  Fly   259 WIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALME 316
            ::.......|:...:|.|||| .|..|....: ..|||.::|.:.:....|..::|:|
Worm   547 YVPYNYEDVRIITPITVLLTL-VQMEKGDKEI-RTSYLTSIDVWFAAMKSFTVLSLLE 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:273305	72/253 (28%)
		Neur_chan_LBD	38..235	CDD:280998	51/170 (30%)
		Neur_chan_memb	243..>334	CDD:280999	19/74 (26%)
lgc-43	NP_001023062.1	LGIC_ECD_anion	344..523	CDD:349788	51/170 (30%)
		LGIC_TM	527..665	CDD:365787	20/78 (26%)
		TM1 helix	527..551	CDD:349850	5/23 (22%)
		TM2 helix	555..577	CDD:349850	8/22 (36%)
		TM3 helix	583..609	CDD:349850	4/20 (20%)
		TM4 helix	610..665	CDD:349850
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614790at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920