Protein Alignment ort and GABRR2

DIOPT Version :10

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_002034.3
• Gene: GABRR2 / 2570
• HGNCID: 4091
• Length: 465
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 154/527 - (29%)
• Similarity: 245/527 - (46%)
• Gaps: 117/527 - (22%)

  Fly     4 QIIILVICTICMKHYAKGE----------------FQQSLAITDI---LPEDIKRYDK----MRP 45
            ::|:.:.|.:.:....|.:                ::::|.:|.|   .|:.:.|.|:    |||
Human     6 RLILFLFCLMVLVESRKPKRKRWTGQVEMPKPSHLYKKNLDVTKIRKGKPQQLLRVDEHDFSMRP 70

  Fly    46 PKKEGQPTI-VYFHVTVMGLDSIDENSMTYVADVFFAQTWKDHRLRLP----ENMTQEYRLLEVD 105
              ..|.|.| |...|.|..||||.|..|.:...::....|||.||...    ::||.:.||
Human    71 --AFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASNKSMTFDGRL---- 129

  Fly   106 WLKNMWRPDSFFKNAK-SVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQEC 169
             :|.:|.||.||.::| |.|..| |..|..:.::.|..:||.:::|:...|.|:|:.:|.|:|.|
Human   130 -VKKIWVPDVFFVHSKRSFTHDT-TTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSHFPLDSQTC 192

  Fly   170 KLQMESLSHTTDDLIFQW-DPTTPLVVDENIELPQVALIRNETADCTQVY-STGNFTCLEVVFTL 232
            .|::||.::|.:||:..| :....|..||.|.|.|..:.:..|......| |||.:..|.:.|||
Human   193 SLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLAFYSSTGWYNRLYINFTL 257

  Fly   233 KRRLVYYVFNTYIPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLK 297
            :|.:.:::..||.|..::|::|||||||...|.||||:||:|::||::|......:|:|.|||:|
Human   258 RRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTVLTMTTIITGVNASMPRVSYVK 322

  Fly   298 AVDAFMSVCTVFVFMALMEYCLINIVLS-----------DTPIPKPMAYPPKPVAGDGPKKEGEG 351
            |||.::.|..||||::::||..:|.:.:           ..|....|.: .|.:..||...|.|
Human   323 AVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLREKFPCMCGMLH-SKTMMLDGSYSESE- 385

  Fly   352 APPGGSNSTASKQQATMLPLADEKIEKIEKIFDEMTKNRRIVTTTRRVVRPPLDADGPWIPRQES 416
                 :||.|...::.:| ..:|:.:||                   ||...|..:.
Human   386 -----ANSLAGYPRSHIL-TEEERQDKI-------------------VVHLGLSGEA-------- 417

  Fly   417 RIILTPTIAPPPPPPQPAAPEPELPKPKL-------TPAQERLKRAIYIDRSSRVLFPALFASLN 474
                            .||.:..|.|.:.       |.|         ||:.||::|||.:...|
Human   418 ----------------NAARKKGLLKGQTGFRIFQNTHA---------IDKYSRLIFPASYIFFN 457

  Fly   475 GIYWCVF 481
            .|||.||
Human   458 LIYWSVF 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:455710	147/482 (30%)
		LGIC_ECD_HisCl	51..235	CDD:349793	65/191 (34%)
		Cys-loop	155..169	CDD:349793	6/13 (46%)
GABRR2	NP_002034.3	LIC	51..464	CDD:455710	146/480 (30%)
		LGIC_ECD_GABAAR_rho	76..261	CDD:349806	65/190 (34%)
		Cys-loop	178..192	CDD:349806	6/13 (46%)