Protein Alignment ort and GABRG3

DIOPT Version :9

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: XP_011519732.1
• Gene: GABRG3 / 2567
• HGNCID: 4088
• Length: 473
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 144/553 - (26%)
• Similarity: 223/553 - (40%)
• Gaps: 157/553 - (28%)

  Fly     6 IILVICTICMKH-----YAKGEFQQSLA--------------ITDILPEDIKRYDKMRPPKKEGQ 51
            ::|::|.....|     ..:.|::.|.:              :|.||.:.::.|||...|....:
Human     5 LLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRPDIGIK 69

  Fly    52 PTIVYFHVTVMGLDSIDENSMTYVADVFFAQTWKDHRLRLPENMTQEYRLLEVDWLKNMWRPDSF 116
            ||::...:.|..:..:...:|.|..|:||||||.|.|||.  |.|.:...|..:.:..:|.||:.
Human    70 PTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRF--NSTMKILTLNSNMVGLIWIPDTI 132

  Fly   117 FKNAKSVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTD 181
            |:|:|:.....:|.||..:.::.|..|||.::||:...|.:....:|.|...|.|...|..:..:
Human   133 FRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPKE 197

  Fly   182 DLIFQWDPTTPLVVDE-NIELPQVAL--IRNETADCTQVYSTGNFTCLEVVFTLKRRLVYYVFNT 243
            ::|::|...:....|: :..|.|...  :||.|...|.  |.|::..:.:.|.|.||:.|:...|
Human   198 EMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTT--SAGDYVVMTIYFELSRRMGYFTIQT 260

  Fly   244 YIPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTV 308
            |||..:.|::||||||||.:|.|||..||:|::||::|....::.|||.|||:.|:|.|::||.:
Human   261 YIPCILTVVLSWVSFWIKKDATPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFL 325

  Fly   309 FVFMALMEYCLINIVLSDTPIPKPMAYPPKPVAGDGPKKEGEGAPPGGSNSTASKQQATMLPLAD 373
            |||.|||||..:|...|   ..||
Human   326 FVFAALMEYATLNYYSS---CRKP----------------------------------------- 346

  Fly   374 EKIEKIEKIFDEMTKNRRIVTTTRRVVRPPLDADGPWIPRQES------RIIL-TPTIAPPPPPP 431
                                |||::...........|||.:.|      ||.| ..::....|||
Human   347 --------------------TTTKKTTSLLHPDSSRWIPERISLQAPSVRIALQNYSLLDMRPPP 391

  Fly   432 QPAAPEPELPKPKLTPAQERLKRAIY--------------------------------------- 457
                           .|...|..::|
Human   392 ---------------TAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSWRKGRIH 441

  Fly   458 -----IDRSSRVLFPALFASLNGIYWCVFYEYL 485
                 :|..|||.||..|...|.:|| |.|.||
Human   442 IDILELDSYSRVFFPTSFLLFNLVYW-VGYLYL 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:273305	134/503 (27%)
		Neur_chan_LBD	38..235	CDD:280998	57/199 (29%)
		Neur_chan_memb	243..>334	CDD:280999	46/90 (51%)
GABRG3	XP_011519732.1	Neur_chan_LBD	48..253	CDD:280998	61/208 (29%)
		LIC	50..470	CDD:273305	135/503 (27%)
		Neur_chan_memb	260..467	CDD:280999	70/285 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810