Protein Alignment ort and GABRG2

DIOPT Version :9

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_944493.2
• Gene: GABRG2 / 2566
• HGNCID: 4087
• Length: 515
• Species: Homo sapiens
• Alignment Length: 524
• Identity: 141/524 - (26%)
• Similarity: 224/524 - (42%)
• Gaps: 141/524 - (26%)

  Fly    29 ITDILPEDIKRYDKMRPPKKEGQPTIVYFHVTVMGLDSIDENSMTYVADVFFAQTWKDHRLRLPE 93
            :|.||...::.||....|....:||:::..:.|..:..::..:|.|..|:||||||.|.||:.
Human    66 VTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKF-- 128

  Fly    94 NMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIMN 158
            |.|.:...|..:.:..:|.||:||:|:|......:|.||..:.::.|..:||.::||:...|.:.
Human   129 NSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQ 193

  Fly   159 FAIYPHDTQECKLQMESLSH----------------------TTD------------------DL 183
            ...:|.|...|.|:..|.|.                      :||                  ::
Human   194 LHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYPREEI 258

  Fly   184 IFQWDPTTPLVVD-ENIELPQVALI--RNETADCTQVYST--GNFTCLEVVFTLKRRLVYYVFNT 243
            ::||..::..|.| .:..|.|.:.:  ||    .|:|..|  |::..:.|.|.|.||:.|:...|
Human   259 VYQWKRSSVEVGDTRSWRLYQFSFVGLRN----TTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQT 319

  Fly   244 YIPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTV 308
            |||..:||::|||||||..:|.|||.:||:|::||::|....::.|||.|||:.|:|.|:|||.:
Human   320 YIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFI 384

  Fly   309 FVFMALMEYCLINIVLSDTPIPKPMAYPPKPVAGDGPKKEGE-------GAP-----PGGSNSTA 361
            |||.||:||..::..:|:.          ||......||:..       .||     |  .::|.
Human   385 FVFSALVEYGTLHYFVSNR----------KPSKDKDKKKKNPLLRMFSFKAPTIDIRP--RSATI 437

  Fly   362 SKQQATMLPLADEK--IEKIEK--------IFDEMTKNRRIVTTTRRVVRPPLDADGPWIPRQES 416
            ....||.|...||:  .|.::.        .|::.                   ..|.|   :..
Human   438 QMNNATHLQERDEEYGYECLDGKDCASFFCCFEDC-------------------RTGAW---RHG 480

  Fly   417 RIILTPTIAPPPPPPQPAAPEPELPKPKLTPAQERLKRAIYIDRSSRVLFPALFASLNGIYWCVF 481
            ||.:                                 |...:|..:|:.||..|...|.:|| |.
Human   481 RIHI---------------------------------RIAKMDSYARIFFPTAFCLFNLVYW-VS 511

  Fly   482 YEYL 485
            |.||
Human   512 YLYL 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:273305	136/516 (26%)
		Neur_chan_LBD	38..235	CDD:280998	60/241 (25%)
		Neur_chan_memb	243..>334	CDD:280999	43/90 (48%)
GABRG2	NP_944493.2	LIC	69..512	CDD:273305	137/516 (27%)
		Neur_chan_LBD	69..312	CDD:280998	63/248 (25%)
		Neur_chan_memb	319..509	CDD:280999	69/256 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810