Protein Alignment ort and GABRG1

DIOPT Version :9

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_775807.2
• Gene: GABRG1 / 2565
• HGNCID: 4086
• Length: 465
• Species: Homo sapiens
• Alignment Length: 479
• Identity: 137/479 - (28%)
• Similarity: 214/479 - (44%)
• Gaps: 99/479 - (20%)

  Fly    29 ITDILPEDIKRYDKMRPPKKEGQPTIVYFHVTVMGLDSIDENSMTYVADVFFAQTWKDHRLRLPE 93
            ||.||...::.||....|....:||::...|.|..:..:|..:|.|..|:.|||||.|.||:.
Human    64 ITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKF-- 126

  Fly    94 NMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIMN 158
            |.|.:..:|..:.:..:|.||:||:|::......:|.||..:.::.|..:||.::||:...|.:.
Human   127 NSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLTINAECYLQ 191

  Fly   159 FAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTPLVVDENI-ELPQVALI--RNETADCTQVYST 220
            ...:|.|...|.|:..|..:..:::.::|...:..|.|... .|.|.|.:  ||.| :.|...|
Human   192 LHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLRNST-EITHTIS- 254

  Fly   221 GNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAK 285
            |::..:.:.|.|.||:.|:...||||..:.|::|||||||..:|.|||.:||:|::||::|....
Human   255 GDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTI 319

  Fly   286 SQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLINIVLSDTPIPKPMAYPPKPVAGDGPKKEGE 350
            ::.|||.|||:.|:|.|:|||.:|||.|||||..::...|:        ...|....|...|...
Human   320 ARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSN--------QKGKTATKDRKLKNKA 376

  Fly   351 GAPPG---GSNSTASKQQATMLPLADEKIEKIEK----------------IFDEMTKNRRIVTTT 396
            ...||   ||         |::|:.:..:.:.:.                .|::.
Human   377 SMTPGLHPGS---------TLIPMNNISVPQEDDYGYQCLEGKDCASFFCCFEDC---------- 422

  Fly   397 RRVVRPPLDADGPWIPRQESRIILTPTIAPPPPPPQPAAPEPELPKPKLTPAQERLKRAIYIDRS 461
                     ..|.|   :|.||.:                                 |...||..
Human   423 ---------RTGSW---REGRIHI---------------------------------RIAKIDSY 442

  Fly   462 SRVLFPALFASLNGIYWCVFYEYL 485
            ||:.||..||..|.:|| |.|.||
Human   443 SRIFFPTAFALFNLVYW-VGYLYL 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:273305	131/471 (28%)
		Neur_chan_LBD	38..235	CDD:280998	56/199 (28%)
		Neur_chan_memb	243..>334	CDD:280999	43/90 (48%)
GABRG1	NP_775807.2	LIC	66..462	CDD:273305	132/472 (28%)
		LGIC_ECD_GABAAR_G	88..269	CDD:349801	52/184 (28%)
		Cys-loop	188..202	CDD:349801	3/13 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810