Protein Alignment ort and GABRB3

DIOPT Version :9

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_000805.1
• Gene: GABRB3 / 2562
• HGNCID: 4083
• Length: 473
• Species: Homo sapiens
• Alignment Length: 505
• Identity: 144/505 - (28%)
• Similarity: 245/505 - (48%)
• Gaps: 70/505 - (13%)

  Fly     2 VFQIIILVICTICMKHYAKGEFQQSLAITDILPEDIKRYDKMRPPKKEGQPTIVYFHVTVMGLDS 66
            :|...:|| ..:|...........|. :.:.:.:.:|.||....|...|.|..|..::.:..:|.
Human    12 IFSAPVLV-AVVCCAQSVNDPGNMSF-VKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDM 74

  Fly    67 IDENSMTYVADVFFAQTWKDHRLR---LPENMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTM 128
            :.|.:|.|...::|.|.|:|.||.   :|.|:|.:.|:.:     .:|.||::|.|.|......:
Human    75 VSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVAD-----QLWVPDTYFLNDKKSFVHGV 134

  Fly   129 TIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTPL 193
            |:.|..:.|:.|.|:||.:::|...:|:|:...||.|.|.|.|::||..:||||:.|.|......
Human   135 TVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKA 199

  Fly   194 VVD-ENIELPQVALIRNETADCTQVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVS 257
            |.. |.|||||.:::.:.......|::||.:..|.:.|.|||.:.|::..||:|:.:|.|:||||
Human   200 VTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVS 264

  Fly   258 FWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLINI 322
            |||..:|:.|||.||:|::||::|.:...:.:||.:.|:||:|.::..|.||||:||:||..:|.
Human   265 FWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNY 329

  Fly   323 VLSDTPIPKPMAYPPKPVAGDGPKKEGE------GAPPGGSNSTASKQQA------TMLPLADEK 375
            :.                .|.||:::.:      .|....|.|.:::..|      |.|.:.:|.
Human   330 IF----------------FGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEM 378

  Fly   376 IEKIEKIFDEMTKNRRIVTTTR----RVVRPPLDADGPW-----IPRQESRIILTPTIAPPPPPP 431
            .|....|.|  |:|..|.....    |....|.:..|.:     :|.:::.:
Human   379 NEVSGGIGD--TRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHL------------- 428

  Fly   432 QPAAPEPELPKPKLTPAQERLKRAIYIDRSSRVLFPALFASLNGIYWCVF 481
            :..:.:.::..|.||....       |||.||::||..|:..|.:||..:
Human   429 RRRSSQLKIKIPDLTDVNA-------IDRWSRIVFPFTFSLFNLVYWLYY 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:273305	139/474 (29%)
		Neur_chan_LBD	38..235	CDD:280998	65/200 (33%)
		Neur_chan_memb	243..>334	CDD:280999	38/90 (42%)
GABRB3	NP_000805.1	LIC	10..471	CDD:273305	144/503 (29%)
		Benzamidine binding, agonist. /evidence=ECO:0000269|PubMed:24909990	120..122		1/1 (100%)
		Benzamidine binding, agonist. /evidence=ECO:0000269|PubMed:24909990, ECO:0007744|PDB:4COF	180..182		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810