DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ort and GABRB1

DIOPT Version :9

Sequence 1:NP_524406.1 Gene:ort / 45910 FlyBaseID:FBgn0003011 Length:485 Species:Drosophila melanogaster
Sequence 2:NP_000803.2 Gene:GABRB1 / 2560 HGNCID:4081 Length:474 Species:Homo sapiens


Alignment Length:512 Identity:147/512 - (28%)
Similarity:246/512 - (48%) Gaps:87/512 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 FQIIILVICTICMKHYAKGEFQQSLAITDILPEDIKRYDKMRPPKKEGQPTIVYFHVTVMGLDSI 67
            |.::|.::|  |.  ::..|......:.:.:...:|.||....|...|.|..|...:.|..:|.:
Human    15 FPVMITMVC--CA--HSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMV 75

  Fly    68 DENSMTYVADVFFAQTWKDHRLR---LPENMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTMT 129
            .|.:|.|...::|.|:|||.||.   :|.|:|.:.|:.:     .:|.||::|.|.|......:|
Human    76 SEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVAD-----QLWVPDTYFLNDKKSFVHGVT 135

  Fly   130 IPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTPLV 194
            :.|..:.|:.|.|:||.:::|...:|:|:...||.|.|.|.|::||..:||||:.|.|:.....|
Human   136 VKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAV 200

  Fly   195 VDEN-IELPQVALIRNETADCTQVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVSF 258
            ...| |||||.:::..:.......::||.:..|.:.|.|||.:.|::..||:|:.:|.|:|||||
Human   201 TGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSF 265

  Fly   259 WIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLINIV 323
            ||..:|:.|||.||:|::||::|.....:.:||.:.|:||:|.::..|.||||:||:||..:|.:
Human   266 WINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYI 330

  Fly   324 LSDTPIPKPMAYPPKPVAGDGPKKEGEGAPPGGSNSTASKQQATMLPLADEKIEKIEKIFDEMTK 388
            .                .|.||:|:|           ||||..:    |:|| .|:|....::..
Human   331 F----------------FGKGPQKKG-----------ASKQDQS----ANEK-NKLEMNKVQVDA 363

  Fly   389 NRRIVTTTRRVVRPPLDADGPWIPRQES--RIILTPTIAPPPPPPQPAAPEPELPKPKLT----- 446
            :..|:.:|..:             |.|:  ..:||....|........:...:..||..:     
Human   364 HGNILLSTLEI-------------RNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYG 415

  Fly   447 --------PAQERLKRAI--------------YIDRSSRVLFPALFASLNGIYWCVF 481
                    |::.|::|..              .||:.||:.||..|:..|.:||..:
Human   416 RALDRHGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYY 472

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ortNP_524406.1 LIC 31..481 CDD:273305 142/482 (29%)
Neur_chan_LBD 38..235 CDD:280998 66/200 (33%)
Neur_chan_memb 243..>334 CDD:280999 38/90 (42%)
GABRB1NP_000803.2 LIC 9..472 CDD:273305 147/510 (29%)
Agonist binding. /evidence=ECO:0000250 120..122 1/1 (100%)
Agonist binding. /evidence=ECO:0000250 180..182 1/1 (100%)
Allosteric effector binding. /evidence=ECO:0000250 290..311 6/20 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3644
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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