Protein Alignment ort and GABRA4

DIOPT Version :9

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_000800.2
• Gene: GABRA4 / 2557
• HGNCID: 4078
• Length: 554
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 149/558 - (26%)
• Similarity: 236/558 - (42%)
• Gaps: 113/558 - (20%)

  Fly     3 FQIIILVICTICMKHYAKGEFQQSLAI-----TDILPEDIKRYDKMRPPKKEGQPTIVYFHVTVM 62
            |.::..:...:|:.. :.|:.|:...:     |.||...:..||....|...|..|.|...:.|.
Human    18 FALLRFLCLAVCLNE-SPGQNQKEEKLCTENFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVT 81

  Fly    63 GLDSIDENSMTYVADVFFAQTWKDHRLRL--PENMTQEYRLLEVDWLKNM-----WRPDSFFKNA 120
            ....:.:..|.|..||||.|||.|.||:.  |         :|:..|.||     |.||:||:|.
Human    82 SFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGP---------IEILRLNNMMVTKVWTPDTFFRNG 137

  Fly   121 KSVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIF 185
            |......||.||....:.::.||||.::||:...|.|....:|.|...|.|:..|.::...::|:
Human   138 KKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIY 202

  Fly   186 QWDPTTPLVVD---ENIELPQVALIRNETADCTQVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPT 247
            .|.......|:   |:..|.|..||....:..|....||.:..:.|.|.|:|::.|::..||||.
Human   203 TWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPC 267

  Fly   248 CMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFM 312
            .|.||:|.|||||..|:.|||...|:|::||::|....::.|||.|||..|:|.|::||..|||.
Human   268 IMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFS 332

  Fly   313 ALMEYCLINIVLS--------DTPIPKPMAYPPKPVAGDGPKKEGEGAPPGGSNSTASKQQAT-M 368
            ||:|:..:|...:        .|..| |...|..||    .:::...||...:|:..:.::.| .
Human   333 ALIEFAAVNYFTNIQMEKAKRKTSKP-PQEVPAAPV----QREKHPEAPLQNTNANLNMRKRTNA 392

  Fly   369 LPLADEKIEKIEKIFDEMTKNRRIVTTTRRVVRPPLDADGP------------------------ 409
            |..::..:....::.:..:|:..:|..:.:.......|..|
Human   393 LVHSESDVGNRTEVGNHSSKSSTVVQESSKGTPRSYLASSPNPFSRANAAETISAARALPSASPT 457

  Fly   410 -----WIPRQES---------------RIILTP---------TIAPPP--PPPQPAAPEPELPKP 443
                 ::||:.|               ||..|.         :..|||  |||..:....
Human   458 SIRTGYMPRKASVGSASTRHVFGSRLQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSK----- 517

  Fly   444 KLTPAQERLKRAIYIDRSSRVLFPALFASLNGIYWCVF 481
                          ||:.:|:|||..|.:.|.:||.|:
Human   518 --------------IDKYARILFPVTFGAFNMVYWVVY 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:273305	143/523 (27%)
		Neur_chan_LBD	38..235	CDD:280998	62/206 (30%)
		Neur_chan_memb	243..>334	CDD:280999	43/98 (44%)
GABRA4	NP_000800.2	Neur_chan_LBD	13..541	CDD:332142	148/556 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..381		8/35 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..435		4/37 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	452..471		3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	495..515		6/19 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810