DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ort and GABRA3

DIOPT Version :9

Sequence 1:	NP_524406.1	Gene:	ort / 45910	FlyBaseID:	FBgn0003011	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_000799.1	Gene:	GABRA3 / 2556	HGNCID:	4077	Length:	492	Species:	Homo sapiens

Alignment Length:	476	Identity:	136/476 - (28%)
Similarity:	211/476 - (44%)	Gaps:	89/476 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TDILPEDIKRYDKMRPPKKEGQPTIVYFHVTVMGLDSIDENSMTYVADVFFAQTWKDHRLRLPEN 94
            |.||...:..||....|......|.|...:.|.....:.:..|.|..||||.|||.|.||:....
Human    68 TRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGP 132

  Fly    95 MTQEYRLLEVDWL--KNMWRPDSFFKNAKSVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIM 157
            |    ::|.::.|  ..:|.||:||.|.|......||.||..:.|..:.|:||.::||:...|.|
Human   133 M----KILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPM 193

  Fly   158 NFAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTPLVVDENIELPQ----------------VAL 206
            :...:|.|...|.|:..|.::||.::::.|    .|..::::|:.|                ..:
Human   194 HLEDFPMDVHACPLKFGSYAYTTAEVVYSW----TLGKNKSVEVAQDGSRLNQYDLLGHVVGTEI 254

  Fly   207 IRNETADCTQVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVSFWIKPEAAPARVTL 271
            ||:         |||.:..:...|.|||::.|:|..||:|..|.||:|.||||:..|:.|||...
Human   255 IRS---------STGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVF 310

  Fly   272 GVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLINIVLSDTPIPKPMAYP 336
            |||::||::|....:::|||.|:|..|:|.|::||..|||.||:|:..:|....     :..|:.
Human   311 GVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTK-----RSWAWE 370

  Fly   337 PKPVAGDGPKKEGEGAPPGGSNSTASKQQATMLPLADEKIEKIEKIFDEMTKNRRIVTTTRRVVR 401
            .|.|......|:...|.|....||......|..|:             .:.|:....|.::...
Human   371 GKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPI-------------NLAKDTEFSTISKGAA- 421

  Fly   402 PPLDADGPWIPRQESRIILTPTIAPPPPPPQPAAPEPELPKPKLT-----PAQERLKRAI-YIDR 460
                      |...|    ||||               :..||.|     |.:.:...:: .:|:
Human   422 ----------PSASS----TPTI---------------IASPKATYVQDSPTETKTYNSVSKVDK 457

  Fly   461 SSRVLFPALFASLNGIYWCVF 481
            .||::||.|||..|.:||..:
Human   458 ISRIIFPVLFAIFNLVYWATY 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:273305	135/473 (29%)
		Neur_chan_LBD	38..235	CDD:280998	59/214 (28%)
		Neur_chan_memb	243..>334	CDD:280999	38/90 (42%)
GABRA3	NP_000799.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..54
		LIC	69..478	CDD:273305	135/473 (29%)
		LGIC_ECD_GABAAR_A3	75..274	CDD:349837	59/215 (27%)
		Cys-loop	191..205	CDD:349837	4/13 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810