Protein Alignment ort and Glrb

DIOPT Version :10

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_445748.1
• Gene: Glrb / 25456
• RGDID: 2706
• Length: 496
• Species: Rattus norvegicus
• Alignment Length: 521
• Identity: 161/521 - (30%)
• Similarity: 262/521 - (50%)
• Gaps: 77/521 - (14%)

  Fly     3 FQIIILVICTICMKHYA----KGEFQQSLAITDILPEDIKR----------------YDKMRPPK 47
            |.::.|:....|.|..:    ||:.:|.|..:....||:.|                ||....|.
  Rat    10 FILMSLLFEDACSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPPNSTSNILNRLLVSYDPRIRPN 74

  Fly    48 KEGQPTIVYFHVTVMGLDSIDENSMTYVADVFFAQTWKDHRLRLPENMTQEYR---LLEVD--WL 107
            .:|.|..|..::.:....||.|.:|.|..::|..|.|.|.||:||    .::|   .|.||  ..
  Rat    75 FKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLP----SDFRGSDALTVDPTMY 135

  Fly   108 KNMWRPDSFFKNAKSVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQ 172
            |.:|:||.||.|.||..|..:|..|..:::::|..:|..::|::.|||.::..::|.|||.||:|
  Rat   136 KCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQ 200

  Fly   173 MESLSHTTDDLIFQWDPTTPLVVDENIELPQVALIRN--ETADCTQVY-STGNFTCLEVVFTLKR 234
            :||..:|||||.|.|....|:.: |.|.|||..:.:.  |..:||:.| .||.:||:||:|||:|
  Rat   201 LESFGYTTDDLRFIWQSGDPVQL-EKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRR 264

  Fly   235 RLVYYVFNTYIPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAV 299
            ::.:|:...|.||.:||::||:||||.|:|:.|||.||:.|:|:|:::.....:.||.|||:||:
  Rat   265 QVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKAL 329

  Fly   300 DAFMSVCTVFVFMALMEYCLINIVLSDTPIPKPM----AYPPKPVAGDGPKKEGEGAPPGGSNST 360
            |.::..|.:|.|.:|:||.::.::|::   ||.:    |...|....||  |.|..|.....|.|
  Rat   330 DVWLIACLLFGFASLVEYAVVQVMLNN---PKRVEAEKARIAKAEQADG--KGGNAAKKNTVNGT 389

  Fly   361 ASKQQATMLPLADEKIEKIEKIFDEMTKN---------RRIVTTTRRVVRPPLDA-DGPWIPRQE 415
            .:....:.|.:.:.:.:|:.....::..|         |....:.......|::. :|...|:.:
  Rat   390 GTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKPQAK 454

  Fly   416 SRIILTPTIAPPPPPPQPAAPEPELPKPKLTPAQERLKRAIYIDRSSRVLFPALFASLNGIYWCV 480
            ::         .|||.:|..|         |.|:.       ||..:|.|||..|...|.|||.:
  Rat   455 NK---------KPPPAKPVIP---------TAAKR-------IDLYARALFPFCFLFFNVIYWSI 494

  Fly   481 F 481
            :
  Rat   495 Y 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:455710	153/487 (31%)
		LGIC_ECD_HisCl	51..235	CDD:349793	72/191 (38%)
		Cys-loop	155..169	CDD:349793	5/13 (38%)
Glrb	NP_445748.1	LIC	43..495	CDD:455710	153/486 (31%)
		LGIC_ECD_GlyR_beta	79..265	CDD:349811	72/190 (38%)
		Cys-loop	183..197	CDD:349811	5/13 (38%)