DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ort and Glra2

DIOPT Version :9

Sequence 1:	NP_524406.1	Gene:	ort / 45910	FlyBaseID:	FBgn0003011	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_036700.1	Gene:	Glra2 / 24397	RGDID:	2705	Length:	452	Species:	Rattus norvegicus

Alignment Length:	477	Identity:	159/477 - (33%)
Similarity:	241/477 - (50%)	Gaps:	71/477 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CMKHYAK-GEF-QQSLAITDILPEDIKR---YDKMRPPKKEGQPTIVYFHVTVMGLDSIDENSMT 73
            |..|.:: |:. .|:|:.:|.|.:.:.|   ||....|..:|.|..|..::.:....|:.|.:|.
  Rat    27 CKDHDSRSGKHPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMD 91

  Fly    74 YVADVFFAQTWKDHRL---RLPENMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTMTIPNHYM 135
            |..::|..|.|.|.||   ..|::...    |:...|.::|:||.||.|.|...|..:|..|..:
  Rat    92 YRVNIFLRQQWNDSRLAYSEYPDDSLD----LDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLL 152

  Fly   136 WLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTPLVVDENIE 200
            .:.|:..:||.::|||.|||.|:...:|.|.|.|.:|:||..:|.:||||:|....|:.|.|.:.
  Rat   153 RISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLT 217

  Fly   201 LPQVAL-IRNETADCTQVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVSFWIKPEA 264
            |||..| ...|...||:.|:||.|||:||.|.|:|::.||:...|||:.:|||:|||||||..:|
  Rat   218 LPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDA 282

  Fly   265 APARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLINIVLSDTPI 329
            |||||.||:|::||::||.:.|::|||.|||:||:|.:|:||.:|||.||:||..:|.|
  Rat   283 APARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFV------ 341

  Fly   330 PKPMAYPPKPVAGDGPKKEGEGAPPGGSNSTASKQQATMLPLADEKIEKIEKIFDEMTKNRRIVT 394
                                            |:|....|.|  .:.:|.:...:::|:..|...
  Rat   342 --------------------------------SRQHKEFLRL--RRRQKRQNKEEDVTRESRFNF 372

  Fly   395 TTRRVVRPPLDADGPWIPRQESRIILTPTIAPPPPPPQPAAPEPELPKPKLTPAQERLKRAIYID 459
            :...:        |..:..::...:......|.|.||:.|    :..|.|..   :|.||   ||
  Rat   373 SGYGM--------GHCLQVKDGTAVKATPANPLPQPPKDA----DAIKKKFV---DRAKR---ID 419

  Fly   460 RSSRVLFPALFASLNGIYWCVF 481
            ..||..||..|...|..||..:
  Rat   420 TISRAAFPLAFLIFNIFYWITY 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:273305	154/456 (34%)
		Neur_chan_LBD	38..235	CDD:280998	73/203 (36%)
		Neur_chan_memb	243..>334	CDD:280999	48/90 (53%)
Glra2	NP_036700.1	LIC	46..441	CDD:273305	154/456 (34%)
Glra2	NP_036700.1	Strychnine-binding. /evidence=ECO:0000250\|UniProtKB:O93430	236..241		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45222
OrthoDB	1	1.010	-	-		D276914at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.030