Protein Alignment ort and GABRR3

DIOPT Version :10

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_001099050.1
• Gene: GABRR3 / 200959
• HGNCID: 17969
• Length: 467
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 143/515 - (27%)
• Similarity: 225/515 - (43%)
• Gaps: 126/515 - (24%)

  Fly    11 CTICMKHYAKGEFQQSLAITDILPEDIKRYD--KMRPPKKE-----------------GQPTIVY 56
            |:..||...|.|.:            :|:.|  |.||.|.|                 |.|..|.
Human    34 CSSSMKQTCKQETR------------MKKDDSTKARPQKYEQLLHIEDNDFAMRPGFGGSPVPVG 86

  Fly    57 FHVTVMGLDSIDENSMTYVADVFFAQTWKDHRLRLP----ENMTQEYRLLEVDWLKNMWRPDSFF 117
            ..|.|..:|||.|.:|.:....:....|||.||..|    ::||.::||     .:.:|.||.||
Human    87 IDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMTFDHRL-----TRKIWVPDIFF 146

  Fly   118 KNAKSVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDD 182
            .::|.......|:.|..:.::.|..:|..:::|:...|.|:|:.:|.|||.|.|::||.::..||
Human   147 VHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSRFPLDTQNCSLELESYAYNEDD 211

  Fly   183 LIFQW-DPTTPLVVDENIELPQVALIRNETADCTQVY--STGNFTCLEVVFTLKRRLVYYVFNTY 244
            |:..| .....|..:|::.|.|. .|.:.:|.....:  |||.:..|.:.|.|:|.:.::|..||
Human   212 LMLYWKHGNKSLNTEEHMSLSQF-FIEDFSASSGLAFYSSTGWYNRLFINFVLRRHVFFFVLQTY 275

  Fly   245 IPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVF 309
            .|..::|::|||||||...|.||||:||:|::||:||......:|:|.||||||||.::.|.::|
Human   276 FPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLF 340

  Fly   310 VFMALMEYCLINIVLSDTPIPKPMAYPPKPVAGDGPKKEGE------------GAPPGGSNSTAS 362
            ||::::||..:|.:   |.:.:...:          ||.|:            .|..|..:.:..
Human   341 VFLSVIEYAAVNYL---TTVEERKQF----------KKTGKISRMYNIDAVQAMAFDGCYHDSEI 392

  Fly   363 KQQATMLPLADEKIEKIEKIFDEMTKNRRIVTTTRRVVRPPLDADGPWIPRQES------RIILT 421
            ....|.|.|..|...:.:.|....|.:.|                   |.|::|      |||
Human   393 DMDQTSLSLNSEDFMRRKSICSPSTDSSR-------------------IKRRKSLGGHVGRII-- 436

  Fly   422 PTIAPPPPPPQPAAPEPELPKPKLTPAQERLKRAIYIDRSSRVLFPALFASLNGIYWCVF 481
                                          |:....||..||:|||.::...|..||.|:
Human   437 ------------------------------LENNHVIDTYSRILFPIVYILFNLFYWGVY 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:455710	137/493 (28%)
		LGIC_ECD_HisCl	51..235	CDD:349793	57/190 (30%)
		Cys-loop	155..169	CDD:349793	7/13 (54%)
GABRR3	NP_001099050.1	LIC	55..466	CDD:455710	135/480 (28%)
		LGIC_ECD_GABAAR_rho	82..267	CDD:349806	58/190 (31%)
		Cys-loop	184..198	CDD:349806	7/13 (54%)
		Interaction with SQSTM1. /evidence=ECO:0000250|UniProtKB:P50573	347..448		25/164 (15%)