DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ort and glra4b

DIOPT Version :9

Sequence 1:	NP_524406.1	Gene:	ort / 45910	FlyBaseID:	FBgn0003011	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001189440.1	Gene:	glra4b / 192125	ZFINID:	ZDB-GENE-020402-2	Length:	492	Species:	Danio rerio

Alignment Length:	523	Identity:	165/523 - (31%)
Similarity:	259/523 - (49%)	Gaps:	83/523 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVFQII--ILVICTI------CMKHYAKGEFQQSLAITDILPEDI--------KRYDKMRPPKKE 49
            ::::|:  :|::|.:      |:  ::|.....|:....:.|.|.        ..||....|..:
Zfish     4 VIWRILLELLLVCWMFEGVIRCV--FSKELKSPSVRTKPMSPSDFLDKLMGKTSGYDARIRPNFK 66

  Fly    50 GQPTIVYFHVTVMGLDSIDENSMTYVADVFFAQTWKDHRL---RLPENMTQEYRLLEVDWLKNMW 111
            |.|..|..::.:....||.|.:|.|..:||..|.|.|.||   ..|::...    |:...|.::|
Zfish    67 GPPVNVTCNIFINSFGSITETTMDYRLNVFLRQQWNDPRLAYKEYPDDSLD----LDPSMLDSIW 127

  Fly   112 RPDSFFKNAKSVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESL 176
            :||.||.|.|...|..:|..|..:.::::..:||.::|||.|||.|:...:|.|||.|.:|:||.
Zfish   128 KPDLFFANEKGANFHEVTTDNKLLRIFQNGNVLYSIRLTLILSCPMDLKNFPMDTQTCTMQLESF 192

  Fly   177 SHTTDDLIFQWDPTTPLVVDENIELPQVALIRNETAD---CTQVYSTGNFTCLEVVFTLKRRLVY 238
            .:|.:||||||....|:.|.:::.|||..|  .|..|   ||:.|:||.|||:||.|.|:|::.|
Zfish   193 GYTMNDLIFQWLDEGPVQVADDLMLPQFVL--KEEKDLGYCTKHYNTGKFTCIEVKFHLERQMGY 255

  Fly   239 YVFNTYIPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFM 303
            |:...|||:.:.||:|||||||..:||||||.||:|::||::||.:.|::|||.|||:||:|.:|
Zfish   256 YLIQMYIPSLLTVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWM 320

  Fly   304 SVCTVFVFMALMEYCLINIVLSDTP----IPKPMAYPPKPVAGDG-----PKKEGEGAPPGGSNS 359
            :||.:|||.||:||..:|.|.....    :.:.:....:..|..|     ..|.......||:.|
Zfish   321 AVCLLFVFAALLEYAAVNFVSRQYKEFFRLRRKLRQEQRNRAASGQAGAAETKNKSNNVTGGTPS 385

  Fly   360 TASKQQATMLPLADEKIEKIEKIFDEMTKNRRIVTTTRRVVRP------PLDADGPWIPRQESRI 418
            ..:::|.:                 ...:..::.:..:.:..|      .|..||   |..|:..
Zfish   386 RNAQRQCS-----------------ACAREEQLASQNQDLYFPGFGIDTSLSGDG---PLSEAAA 430

  Fly   419 ILTPTIAPPPPPPQPAAPEPELPKPKLTPAQER-LKRAIYIDRSSRVLFPALFASLNGIYWCVFY 482
            :....      ||..|          |...:.| :::|..||..||.:||..|...|..|| |.|
Zfish   431 MFAGL------PPGHA----------LFDIRRRFVEQAKRIDTISRAVFPLSFLVFNVFYW-VTY 478

  Fly   483 EYL 485
            :.|
Zfish   479 KVL 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:273305	156/479 (33%)
		Neur_chan_LBD	38..235	CDD:280998	75/202 (37%)
		Neur_chan_memb	243..>334	CDD:280999	47/94 (50%)
glra4b	NP_001189440.1	LIC	5..478	CDD:273305	163/517 (32%)
		Neur_chan_LBD	47..253	CDD:280998	76/211 (36%)
		Neur_chan_memb	260..475	CDD:280999	74/250 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276914at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920