Protein Alignment ort and lgc-53

DIOPT Version :10

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_741945.3
• Gene: lgc-53 / 188702
• WormBaseID: WBGene00020657
• Length: 497
• Species: Caenorhabditis elegans
• Alignment Length: 475
• Identity: 130/475 - (27%)
• Similarity: 214/475 - (45%)
• Gaps: 85/475 - (17%)

  Fly    28 AITDILPEDIKR------YDKMRPPKKEGQPTIVYFHVTVMGLDSIDENSMTYVADVFFAQTWKD 86
            ||.:.|.:::.:      |||...|.......||  .:||..:..|.|.|.::.|||:|:|.|:|
 Worm    79 AINETLRKNLLQELFDDSYDKNNLPSANSTEVIV--ELTVQSITEISEFSSSFKADVWFSQIWRD 141

  Fly    87 HRLRLPENMTQEYRLLEVDW----LKNMWRPDSFFKNAKSVTFQTMTIPNHYMWLYKDKTILYMV 147
            .||...:   :.|.|..:..    |..||.|:..|.|:|.|........|..:.::.:.|:....
 Worm   142 PRLDFSD---RNYCLKNISLASHKLPTMWSPNVCFVNSKKVEIHASPSQNILLLIFPNGTVWLNF 203

  Fly   148 KLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIF---QWDPTTPLVVD-ENIELPQVALIR 208
            :::|...|.::...:|.|.|.|.|..||.|:.|.::..   .||..|  :.| ::..||...|:.
 Worm   204 RVSLTGPCKLDLTYFPMDRQSCNLVFESYSYNTAEVRIVWRDWDAVT--IPDPDSKNLPDFELVN 266

  Fly   209 NETADCTQVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVSFWIKPEAAPARVTLGV 273
            .|..:.|.||:.|.:..|||.||.:|...|||...|:||.:.|.:||::|||..:|.|||:||||
 Worm   267 IEHMNATLVYTAGLWDQLEVKFTFRRLYGYYVLQAYMPTYLSVFISWIAFWIDTKALPARITLGV 331

  Fly   274 TSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLINIVLSDTPIPKPMAYPPK 338
            :||:.|:.|......:||.|||:||:|.:|..|..|:|::|:|..
 Worm   332 SSLMALTFQFGNIVKNLPRVSYVKALDIWMFGCVGFIFLSLVELA-------------------- 376

  Fly   339 PVAGDGPKKEGEGAPPGGSNSTASKQQATMLPLADEK-IEKIEKIFDEMTKNRRIVTTTRRVVRP 402
             |.|...|.|.:     .......|:|..|...:::: :.::.....::::.....|.|.::
 Worm   377 -VVGFADKLEAK-----RRRHNRCKEQLMMRSDSEQQWLSRLSGQRPQVSETNSDATHTIQI--- 432

  Fly   403 PLDADGPWIPRQES-----RIILTPTIAPPPPPPQPAAPEPELPKPKLTPAQERLKRAIYIDRSS 462
             .|.:|. :.|::|     :::|                  ::..|.....::       ||..|
 Worm   433 -NDGNGN-VRRRKSEEKRQKLLL------------------QMESPMFVNGEK-------IDEIS 470

  Fly   463 RVLFPALFASLNGIYWCVFY 482
            ..|||.||.:.|..||  ||
 Worm   471 AKLFPLLFTAFNIFYW--FY 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:455710	126/469 (27%)
		LGIC_ECD_HisCl	51..235	CDD:349793	56/191 (29%)
		Cys-loop	155..169	CDD:349793	4/13 (31%)
lgc-53	NP_741945.3	LIC	87..489	CDD:455710	127/467 (27%)
		LGIC_ECD_GABAAR	108..292	CDD:349791	56/190 (29%)
		Cys-loop	211..225	CDD:349791	4/13 (31%)