Protein Alignment ort and lgc-51

DIOPT Version :10

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_001293359.1
• Gene: lgc-51 / 184377
• WormBaseID: WBGene00017399
• Length: 450
• Species: Caenorhabditis elegans
• Alignment Length: 515
• Identity: 130/515 - (25%)
• Similarity: 212/515 - (41%)
• Gaps: 108/515 - (20%)

  Fly     2 VFQIIILVICTICMKHYAKGEFQQS--------LAITDILPEDIKRYDKMRPPKKEGQPTIVYFH 58
            :|..:.:::.|....   :|.|.:.        .||.|::   :..|.:..|    |.|..|...
 Worm     3 LFHFLAVIVTTFAQD---EGSFVEKCTKPRLTPAAILDVI---MANYSRSLP----GNPVGVQVE 57

  Fly    59 VTVMGLDSIDENSMTYVADVFFAQTWKDHRLRLP--ENMTQEYRLLEVD--WLKNMWRPDSFFKN 119
            |||..:..:...|.::.||::|:..|.|.||...  :|..|.   |..|  :.|.:|.|:....|
 Worm    58 VTVQDVMELSVLSNSFTADIWFSSIWYDPRLAYSHLDNCRQN---LSFDDRFEKLIWSPNVCIVN 119

  Fly   120 AKSVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLI 184
            .||........||..:.|..:.||....::.::..|.|:.|.:|.|||.|:|..||.|:.|..:.
 Worm   120 TKSAHVHRSPKPNVLLMLLPNGTIWLNYRIRVQSPCSMDLARFPIDTQYCQLVFESYSYNTASVS 184

  Fly   185 FQWDPTTPLVVDENIELPQVALIRNETADCTQVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPTCM 249
            ..| ...|:.|...|.|....|.|..|:..|:||..|.:..|.|.|...|:..:|:...|:||.:
 Worm   185 VNW-MANPVTVLPEISLADFDLSRYRTSRHTEVYKAGEWYRLTVEFEFTRKYGFYILQLYVPTYI 248

  Fly   250 IVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMAL 314
            .:.:||::|.|..:|.|||:.|||.||::|:.|......|||||||:||:|.:|..|..|:|.:|
 Worm   249 SLFISWIAFCIDTKALPARIVLGVNSLMSLTFQFGNIIRSLPPVSYVKAIDLWMCTCVGFIFASL 313

  Fly   315 MEYCLI-----NIVL----SDTPIPKPMAY------------PPKPVAGDGPKKEGEGAPPGGSN 358
            :|...:     .::|    |:..|...::|            ||.|...|..|....      :.
 Worm   314 LELAFVAYQDKKLILKSGKSNAAISTLVSYLKHFEPYHDVSSPPPPAPLDEKKSMSR------TT 372

  Fly   359 STASKQQATMLPLADEKIEKIEKIFDEMTKNRRIVTTTRRVVRPPLDADGPWIPRQESRIILTPT 423
            ||.:.:..:.|...|.|     .:.:|:.:.|::....::           |
 Worm   373 STGTNRSRSELDGLDTK-----DLEEEIAEYRKLAYARKK-----------W------------- 408

  Fly   424 IAPPPPPPQPAAPEPELPKPKLTPAQERLKRAIYIDRSSRVLFPALFASLNGIYWCVFYE 483
                                      ..|.....:||.|.::||..||:.|.:||..:.:
 Worm   409 --------------------------RLLDFGANVDRISFIVFPLTFAAFNVVYWTYYLQ 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:455710	124/474 (26%)
		LGIC_ECD_HisCl	51..235	CDD:349793	56/187 (30%)
		Cys-loop	155..169	CDD:349793	7/13 (54%)
lgc-51	NP_001293359.1	LIC	34..440	CDD:455710	126/477 (26%)
		LGIC_ECD_GABAAR	52..233	CDD:349791	55/184 (30%)
		Cys-loop	155..169	CDD:349791	7/13 (54%)