Protein Alignment ort and acc-2

DIOPT Version :10

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_501567.1
• Gene: acc-2 / 183758
• WormBaseID: WBGene00008280
• Length: 445
• Species: Caenorhabditis elegans
• Alignment Length: 471
• Identity: 110/471 - (23%)
• Similarity: 187/471 - (39%)
• Gaps: 112/471 - (23%)

  Fly    30 TDILPEDIK--RYDKMRPPKKEGQPTIVYFHVTVMGLDSIDENSMTYVADVFFAQTWKDHRLRLP 92
            |||:...:.  .|:|.|.|::||...:|  .:.:..:.||||.:..:..|::..:||.|..|...
 Worm    51 TDIIDRLLNGTGYNKFRIPQEEGMTVVV--EIWIQAITSIDELTNDFDMDIYITETWLDPALNFQ 113

  Fly    93 E------NMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTMTIPNHYMWLYKDKTILYMVKLTL 151
            .      |::..:::|:     .:|.|:|.|.|:|..........:.::.|:.:.|::...::.:
 Worm   114 TMTPCKGNLSLNHQVLD-----RLWTPNSCFINSKVAQIHNSPFRSVFLMLFPNGTVMVNYRVRV 173

  Fly   152 KLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQW-DPTTPLVVDENIELPQVALIRNETADCT 215
            |..|.::.:.:|.|.|:|.|..||.::...::..:| |...|:.....|.||...|...:|....
 Worm   174 KGPCSLDLSNFPLDLQKCSLIYESFNYNRQEVEMRWSDAEHPVFNLSKIMLPDFDLFEIQTERRQ 238

  Fly   216 QVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLS 280
            :.|..|.:..|.|....:||.::|....|:||.:.:.:||:||.:...|.|||..|||.|||.:.
 Worm   239 EPYPAGMWDELHVTIIFERRFIWYFMQAYLPTYLTIFISWISFSLGSRAIPARTMLGVNSLLAIV 303

  Fly   281 TQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLINIVLSDTPIPKPMAYPPKPVAGDGP 345
            ........:||.|||:|.:|.:|.|...|:|.:|:|..::..::.|..:.|..  ..|.::|:..
 Worm   304 FSFGNIMRNLPRVSYIKGIDVWMLVSMTFIFCSLLELAIVGFMVRDETVAKKK--QQKKISGNIS 366

  Fly   346 KKEGEGA---------PPGGSNSTASKQQATMLPLADEKIEKIEKIFDEMTKNRRIVTTTRRVVR 401
            ::|....         |||.|.|:.|....|
 Worm   367 REESPHGIISERRFMFPPGCSESSKSLSSCT---------------------------------- 397

  Fly   402 PPLDADGPWIPRQESRIILTPTIAPPPPPPQPAAPEPELPKPKLTPAQERLKRAIYIDRSSRVLF 466
                  ..|.|.:                                           ||..|.|:|
 Worm   398 ------SGWTPER-------------------------------------------IDSISSVMF 413

  Fly   467 PALFASLNGIYWCVFY 482
            |..|...|.|||  ||
 Worm   414 PFSFFVFNIIYW--FY 427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:455710	107/467 (23%)
		LGIC_ECD_HisCl	51..235	CDD:349793	41/190 (22%)
		Cys-loop	155..169	CDD:349793	4/13 (31%)
acc-2	NP_501567.1	LIC	52..428	CDD:455710	109/470 (23%)
		LGIC_ECD_GABAAR	76..258	CDD:349791	41/188 (22%)
		Cys-loop	177..191	CDD:349791	4/13 (31%)