Protein Alignment ort and lgc-41

DIOPT Version :10

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_001360683.1
• Gene: lgc-41 / 183331
• WormBaseID: WBGene00008022
• Length: 567
• Species: Caenorhabditis elegans
• Alignment Length: 591
• Identity: 140/591 - (23%)
• Similarity: 228/591 - (38%)
• Gaps: 148/591 - (25%)

  Fly     2 VFQIIILVICTICMKHYAKGEFQQSLAITDILPEDIKRYDKMRPPKKEGQ-PTIVYFHVTVMGLD 65
            :||::.:.|.           .:.|..:|.....::.:....|||..... |..|...:.:..|.
 Worm    10 LFQVLCIFIF-----------IRTSSPLTQPNIYNLLQQSNTRPPTANASVPLGVKLGMYLESLG 63

  Fly    66 SIDENSMTYVADVFFAQTWKDHRLRLPENMTQEYRLLEVDWL-KNMWRPDSFFKNAKSVTFQTMT 129
            :...:.|::..|::...:|:|.  ||..|.: :|.|:..|.: |.:|.||.:|.||:..:||.:|
 Worm    64 NFRSSEMSFDVDLYVYMSWQDP--RLAHNFS-DYVLINNDEIRKQIWLPDLYFANARQASFQEVT 125

  Fly   130 IPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTPLV 194
            :||..:::..|.|:.|..:.||.::|.:|...||.|.|.|.:::.|.::....:...|....|:.
 Worm   126 VPNFNLFVAPDGTVAYSCRCTLTVACSLNLRYYPMDQQLCSIRVLSYAYIAKQVNVTWFDKNPVR 190

  Fly   195 VDENIELPQVALIRNETADCT---------QVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPTCMI 250
            .:|.|.||:..:.....|.|.         ..|.:.:|:||.....|.|.:.|.:..:||||.:|
 Worm   191 FNEEIGLPEFQIEHVSNAYCNGSYQYALTENSYKSDDFSCLSGNLFLSRSIGYNLVQSYIPTGLI 255

  Fly   251 VIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALM 315
            |::|||||||...|.||||||..|:|::|:|.....:..||.|||.||:|.:...|..|||.||:
 Worm   256 VMISWVSFWIDRRAVPARVTLSFTTLVSLTTLGNGLRFGLPQVSYAKAIDLWYGACMFFVFCALL 320

  Fly   316 EYCLINIVLSDTPIPKPMAYPPKPV---------------------------------------- 340
            |:..||..:..:.....||...:.|
 Worm   321 EFATINSYMRKSEKFDSMAKKMQSVVLTGRTRDYLVRGIKESMRIAGGAAGNVVDALNDDWCTYS 385

  Fly   341 -----------AGDGPKKEGEGAPPGGSNSTASKQQA---------TMLPLADEKIEKIEKIFDE 385
                       .||..::.|....|..:.....|.:.         |:..:..|:|:.|:..||.
 Worm   386 TENGRKSFSAMVGDIFERAGNAISPRRNRYRGLKTEKSPRGYGKPDTVQDILSERIKFIDNEFDF 450

  Fly   386 MTK-------------------------------------NRRIVTTTRRVVRPPLDADGPWIPR 413
            .||                                     .|.....||:.:...|:..|    :
 Worm   451 DTKEDDEIPGNMAMSIYDNVSCRKDEADSSSEETKFSTKPKRNGTNGTRKYIDKSLNQSG----Q 511

  Fly   414 QESRIILTPTIAPPPPPPQPAAPEPELPKPKLTPAQERLKRAIYIDRSSRVLFPALFASLNGIYW 478
            .:|.|:.|                      ....:....:.|:.||:|.|.||||.|...|..||
 Worm   512 NDSLIVAT----------------------YFQISANHSRHALKIDKSCRYLFPAAFLLWNVFYW 554

  Fly   479 CVFYEY 484
            ..:..|
 Worm   555 WYYLVY 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:455710	134/557 (24%)
		LGIC_ECD_HisCl	51..235	CDD:349793	51/194 (26%)
		Cys-loop	155..169	CDD:349793	6/13 (46%)
lgc-41	NP_001360683.1	LIC	41..>332	CDD:455710	97/293 (33%)
		LGIC_TM	<527..557	CDD:476813	13/29 (45%)
		TM4 helix	533..554	CDD:349850	10/20 (50%)