Protein Alignment ort and unc-49

DIOPT Version :10

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_001022785.1
• Gene: unc-49 / 176472
• WormBaseID: WBGene00006784
• Length: 506
• Species: Caenorhabditis elegans
• Alignment Length: 535
• Identity: 148/535 - (27%)
• Similarity: 241/535 - (45%)
• Gaps: 103/535 - (19%)

  Fly     3 FQIIILVICTICMKHYAKGEFQQSLAITDILPEDIKR------YDKMRPPKKEGQPTIVYFHVTV 61
            |.:|:|:...:|: |....:.:.|...|.:|...:.|      |||...|:...:|..|...:.|
 Worm     5 FTLIVLLSAHLCL-HVVVTQDEDSHINTQLLSSVLDRLTNRTTYDKRLRPRYGEKPVDVGITIHV 68

  Fly    62 MGLDSIDENSMTYVADVFFAQTWKDHRL---RLPENMTQEYRLLE--VDWLKNMWRPDSFFKNAK 121
            ..:.::.|..|.:..|.:..|||:|.||   .|...:::|...|.  ||:|..:|:||:||.|.|
 Worm    69 SSISAVSEVDMDFTLDFYMRQTWQDPRLAFGSLDLGLSKEIDSLTVGVDYLDRLWKPDTFFPNEK 133

  Fly   122 SVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQ 186
            ...|...|..|.::.:..|.|:....:||:..:|.|:..::|.|:|.|||::||..:.|.|:.:.
 Worm   134 KSFFHLATTHNSFLRIEGDGTVYTSQRLTVTATCPMDLKLFPMDSQHCKLEIESYGYETKDIDYY 198

  Fly   187 W-----DPTTPLVVDENIELPQ-------VALIRNETADCTQVYSTGNFTCLEVVFTLKRRLVYY 239
            |     |.....|..:..:|||       |...:.||       |:|.:..|.:...|.|.:.:|
 Worm   199 WGKKRTDLEITAVKFDTFQLPQFQPTLYFVNTTKAET-------SSGKYVRLALEVILVRNMGFY 256

  Fly   240 VFNTYIPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMS 304
            ..|..||:.:||.:||||||:..||:||||.||||::||::|....:.:|:|.|||:|.:|.|::
 Worm   257 TMNIVIPSILIVTISWVSFWLNREASPARVGLGVTTVLTMTTLITTTNNSMPKVSYVKGLDVFLN 321

  Fly   305 VCTVFVFMALMEYCLINIVLSDTPIPKPMAYPPKPVAGDGPKKEGEGAPPGGSNSTASKQQATML 369
            .|.|.||.:|:||.::             :|..|.:.....|:          ...|.:||...:
 Worm   322 FCFVMVFASLLEYAIV-------------SYMNKRLVLRREKR----------RKAAEQQQRNEM 363

  Fly   370 PLADEKIEKIEKIFDEMTKNRRIVTTTRRVVRP-----------------PLDADGPWIPRQESR 417
            |:.:...:.......|||...:..|..:..|:.                 |.:.|...||..:..
 Worm   364 PMFNASPKAANNNSYEMTLMSQNSTPAKSYVQADLYFAGHNSSMNPLMEIPENCDCRTIPMMQHP 428

  Fly   418 IILTP---TIAPPPPPPQPAAPEPELPKPK---------LTPAQERLKRAIYIDRSSRVLFPALF 470
            .::|.   |:.|.|           ..:||         .|||:        ||:.||..||..|
 Worm   429 RLVTDGAHTLWPAP-----------FARPKKASKTCCQRWTPAK--------IDKLSRYGFPLSF 474

  Fly   471 ASLNGIYWCVFYEYL 485
            :..|.:|| ::.:||
 Worm   475 SIFNIVYW-LYMKYL 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:455710	139/501 (28%)
		LGIC_ECD_HisCl	51..235	CDD:349793	57/200 (29%)
		Cys-loop	155..169	CDD:349793	5/13 (38%)
unc-49	NP_001022785.1	LIC	37..484	CDD:455710	138/496 (28%)