DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ort and avr-14

DIOPT Version :9

Sequence 1:	NP_524406.1	Gene:	ort / 45910	FlyBaseID:	FBgn0003011	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001020963.1	Gene:	avr-14 / 172270	WormBaseID:	WBGene00000232	Length:	430	Species:	Caenorhabditis elegans

Alignment Length:	334	Identity:	121/334 - (36%)
Similarity:	185/334 - (55%)	Gaps:	23/334 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILVICTICMKHYAKGEFQQSLAITDILPEDIKRYD-KMRPP------KKEGQPTIVYFHVTVMGL 64
            ||:|.:|.....||.:.::.    :|:...:|.|| ::||.      ...|.|.:|..::.:..:
Worm     9 ILLIISIIHSIRAKRKLKEQ----EIIQRILKDYDWRVRPRGMNATWPDTGGPVLVTVNIYLRSI 69

  Fly    65 DSIDENSMTYVADVFFAQTWKDHRL---RLPENMTQEYRLLEV-------DWLKNMWRPDSFFKN 119
            ..||:.:|.|.|...|.:.|.|.||   |..|:...|.....|       |..:.:|.||:||:|
Worm    70 SKIDDVNMEYSAQFTFREEWTDQRLAYERYEESGDTEVPPFVVLATSENADQSQQIWMPDTFFQN 134

  Fly   120 AKSVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLI 184
            .|......:..||..:.::|:..|||.|:|:|.|||.|:...||.|.|.|.:.:.|.::||.|:.
Worm   135 EKEARRHLIDKPNVLIRIHKNGQILYSVRLSLVLSCPMSLEFYPLDRQNCLIDLASYAYTTQDIK 199

  Fly   185 FQWDPTTPLVVDENI--ELPQVALIRNETADCTQVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPT 247
            ::|....|:...:.:  .||...|....|..||.:.:||.::|..||..|:|...||:...|||.
Worm   200 YEWKEKKPIQQKDGLRQSLPSFELQDVVTDYCTSLTNTGEYSCARVVLRLRREYSYYLIQLYIPC 264

  Fly   248 CMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFM 312
            .|:|::||||||:..:|.||||:||||:|||::||.:...|.||||||:||||.::.||..|:|.
Worm   265 IMLVVVSWVSFWLDKDAVPARVSLGVTTLLTMTTQASGINSKLPPVSYIKAVDVWIGVCLAFIFG 329

  Fly   313 ALMEYCLIN 321
            ||:||.::|
Worm   330 ALLEYAVVN 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:273305	115/310 (37%)
		Neur_chan_LBD	38..235	CDD:280998	66/215 (31%)
		Neur_chan_memb	243..>334	CDD:280999	45/79 (57%)
avr-14	NP_001020963.1	LIC	20..424	CDD:273305	117/323 (36%)
		Neur_chan_LBD	27..253	CDD:280998	68/229 (30%)
		Neur_chan_memb	260..>355	CDD:280999	45/79 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45222
OrthoDB	1	1.010	-	-		D276914at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.030