DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ort and Glra4

DIOPT Version :9

Sequence 1:	NP_524406.1	Gene:	ort / 45910	FlyBaseID:	FBgn0003011	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_034427.2	Gene:	Glra4 / 14657	MGIID:	95750	Length:	456	Species:	Mus musculus

Alignment Length:	482	Identity:	159/482 - (32%)
Similarity:	243/482 - (50%)	Gaps:	83/482 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 MKHYAKGEFQQSLAITDILPEDIKR---YDKMRPPKKEGQPTIVYFHVTVMGLDSIDENSMTYVA 76
            :|...||  .|.::.:|.|.:.:.|   ||....|..:|.|..|..::.:....|:.|.:|.|..
Mouse    31 VKSGLKG--SQPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRV 93

  Fly    77 DVFFAQTWKDHRL---RLPENMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTMTIPNHYMWLY 138
            :||..|.|.|.||   ..|::...    |:...|.::|:||.||.|.|...|..:|..|..:.::
Mouse    94 NVFLRQQWNDPRLAYREYPDDSLD----LDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIF 154

  Fly   139 KDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTPLV-VDENIELP 202
            |:..:||.::|||.|||.|:...:|.|.|.|.:|:||..:|.:||:|:|....|.| |.|.:.||
Mouse   155 KNGNVLYSIRLTLILSCPMDLKNFPMDIQTCTMQLESFGYTMNDLMFEWLEDAPAVQVAEGLTLP 219

  Fly   203 QVALIRNE--TADCTQVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVSFWIKPEAA 265
            |. ::|:|  ...||:.|:||.|||:||.|.|:|::.||:...|||:.:|||:|||||||..:||
Mouse   220 QF-ILRDEKDLGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAA 283

  Fly   266 PARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLINIVLSDTPIP 330
            ||||.||:|::||::||.:.|::|||.|||:||:|.:|:||.:|||.||:||..:|.|
Mouse   284 PARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFV------- 341

  Fly   331 KPMAYPPKPVAGDGPKKEGEGAPPGGSNSTASKQQATMLPLADEKIEKIEKIFDEMTKNRRIVTT 395
                                           |:|....:.|  .:.::.:::.:::.:..|....
Mouse   342 -------------------------------SRQHKEFMRL--RRRQRRQRMEEDIIRESRFYFR 373

  Fly   396 TRRVVRPPLDADGPWIPRQESRIILTPTIAPPPPPPQPAAPEPELPKPKLTPAQERLKRAIYIDR 460
            ...:.......||.  |.:.|.|.       .|.||.|...|.|            ..|.:|:||
Mouse   374 GYGLGHCLQARDGG--PMEGSSIY-------SPQPPTPLLKEGE------------TMRKLYVDR 417

  Fly   461 S------SRVLFPALFASLNGIYWCVF 481
            :      ||.:||..|...|..||.|:
Mouse   418 AKRIDTISRAVFPFTFLVFNIFYWVVY 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:273305	154/464 (33%)
		Neur_chan_LBD	38..235	CDD:280998	74/205 (36%)
		Neur_chan_memb	243..>334	CDD:280999	48/90 (53%)
Glra4	NP_034427.2	LIC	9..444	CDD:273305	158/480 (33%)
Glra4	NP_034427.2	Strychnine-binding. /evidence=ECO:0000250\|UniProtKB:O93430	236..241		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45222
OrthoDB	1	1.010	-	-		D276914at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930