Protein Alignment ort and Gabrg3

DIOPT Version :10

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: XP_017177467.1
• Gene: Gabrg3 / 14407
• MGIID: 95624
• Length: 468
• Species: Mus musculus
• Alignment Length: 500
• Identity: 149/500 - (29%)
• Similarity: 220/500 - (44%)
• Gaps: 113/500 - (22%)

  Fly    25 QSLAITDILPEDIKRYDKMRPPKKEGQPTIVYFHVTVMGLDSIDENSMTYVADVFFAQTWKDHRL 89
            |...:|.||.:.::.|||...|....:||::...:.|..:..:...:|.|..|:||||||.|.||
Mouse    43 QDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRL 107

  Fly    90 RLPENMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLS 154
            |.  |.|.:...|..:.:..:|.||:.|:|:|:.....:|.||..:.::.|..|||.::||:...
Mouse   108 RF--NSTMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAE 170

  Fly   155 CIMNFAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTPLVVDE-NIELPQVAL--IRNETADCTQ 216
            |.:....:|.|...|.|...|..:..:::|::|...:....|: :..|.|...  :||.|...|.
Mouse   171 CQLQLHNFPMDAHACPLTFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTT 235

  Fly   217 VYSTGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLST 281
              |.|::..:.:.|.|.||:.|:...||||..:.|::||||||||.:|.|||.|||:|::||::|
Mouse   236 --SAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTTLGITTVLTMTT 298

  Fly   282 QHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLINIVLSDTPIPKPMAYPPKPVAGDGPK 346
            ....::.|||.|||:.|:|.|::||.:|||.|||||..:|...|   ..||
Mouse   299 LSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSS---CRKP-------------- 346

  Fly   347 KEGEGAPPGGSNSTASKQQATMLPLADEKIEKIEKIFDEMTKNRRIVTTTRRVVRPPLDADGPWI 411
                         |..|::.:.|...|                     :||            ||
Mouse   347 -------------TIRKKKTSQLLHPD---------------------STR------------WI 365

  Fly   412 PRQESRIILTPTIAPP--------PPPPQPAAPEPELPKPKL--TPAQERL-------------- 452
            |   .||.|.   ||.        ||||........:...:.  |...|.|
Mouse   366 P---DRISLQ---APSNYSLLDMRPPPPVMITLNNSMYWQEFEDTCVYECLDGKDCQSFFCCYEE 424

  Fly   453 -------KRAIYIDRS-----SRVLFPALFASLNGIYWCVFYEYL 485
                   :..|:||.|     |||.||..|...|.:|| |.|.||
Mouse   425 CKSGSWRRGRIHIDVSELDSYSRVFFPTSFLLFNLVYW-VGYLYL 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:455710	143/488 (29%)
		LGIC_ECD_HisCl	51..235	CDD:349793	53/186 (28%)
		Cys-loop	155..169	CDD:349793	3/13 (23%)
Gabrg3	XP_017177467.1	LIC	50..465	CDD:455710	144/488 (30%)
		LGIC_ECD_GABAAR_G	71..252	CDD:349801	52/184 (28%)
		Cys-loop	171..185	CDD:349801	3/13 (23%)