Protein Alignment ort and Gabrg2

DIOPT Version :10

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_032099.1
• Gene: Gabrg2 / 14406
• MGIID: 95623
• Length: 474
• Species: Mus musculus
• Alignment Length: 484
• Identity: 138/484 - (28%)
• Similarity: 222/484 - (45%)
• Gaps: 101/484 - (20%)

  Fly    29 ITDILPEDIKRYDKMRPPKKEGQPTIVYFHVTVMGLDSIDENSMTYVADVFFAQTWKDHRLRLPE 93
            :|.||...::.||....|....:||:::..:.|..:..::..:|.|..|:||||||.|.||:.
Mouse    65 VTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKF-- 127

  Fly    94 NMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIMN 158
            |.|.:...|..:.:..:|.||:||:|:|......:|.||..:.::.|..:||.::||:...|.:.
Mouse   128 NSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQ 192

  Fly   159 FAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTPLVVD-ENIELPQVALI--RNETADCTQVYST 220
            ...:|.|...|.|:..|..:..:::::||..::..|.| .:..|.|.:.:  ||    .|:|..|
Mouse   193 LHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRN----TTEVVKT 253

  Fly   221 --GNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQH 283
              |::..:.|.|.|.||:.|:...||||..:||::|||||||..:|.|||.:||:|::||::|..
Mouse   254 TSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLS 318

  Fly   284 AKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLINIVLSDTPIPKPMAYPPKPVAGDGPKKE 348
            ..::.|||.|||:.|:|.|:|||.:|||.||:||..::..:|:.          ||......||:
Mouse   319 TIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNR----------KPSKDKDKKKK 373

  Fly   349 GE-------GAP-----PGGSNSTASKQQATMLPLADEK--IEKIEK--------IFDEMTKNRR 391
            ..       .||     |  .::|.....||.|...||:  .|.::.        .|::.
Mouse   374 NPLLRMFSFKAPTIDIRP--RSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDC----- 431

  Fly   392 IVTTTRRVVRPPLDADGPWIPRQESRIILTPTIAPPPPPPQPAAPEPELPKPKLTPAQERLKRAI 456
                          ..|.|   :..||.:                                 |..
Mouse   432 --------------RTGAW---RHGRIHI---------------------------------RIA 446

  Fly   457 YIDRSSRVLFPALFASLNGIYWCVFYEYL 485
            .:|..:|:.||..|...|.:|| |.|.||
Mouse   447 KMDSYARIFFPTAFCLFNLVYW-VSYLYL 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:455710	133/476 (28%)
		LGIC_ECD_HisCl	51..235	CDD:349793	54/188 (29%)
		Cys-loop	155..169	CDD:349793	3/13 (23%)
Gabrg2	NP_032099.1	LIC	68..471	CDD:455710	134/476 (28%)
		LGIC_ECD_GABAAR_G	89..270	CDD:349801	53/186 (28%)
		Cys-loop	189..203	CDD:349801	3/13 (23%)