Protein Alignment ort and Gabrd

DIOPT Version :9

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: XP_006538609.2
• Gene: Gabrd / 14403
• MGIID: 95622
• Length: 483
• Species: Mus musculus
• Alignment Length: 517
• Identity: 141/517 - (27%)
• Similarity: 214/517 - (41%)
• Gaps: 148/517 - (28%)

  Fly    24 QQSLAITDI------------LPE-D--IKRYDKMRPPKKEGQPTIVYFHVTVMGLDSIDENSMT 73
            :|:.|:.||            ||. |  ::.|.:...|...|.|..|...:.|..:|.|.|.:|.
Mouse    54 RQARAMNDIGDYVGSNLEISWLPNLDGLMEGYARNFRPGIGGAPVNVALALEVASIDHISEANME 118

  Fly    74 YVADVFFAQTWKDHRLRLPENMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTMTIPNHYMWLY 138
            |...||..|:|:|.||..  |.|.|...|:..::..:|.||:|..||||..|..:|:.|..:.|.
Mouse   119 YTMTVFLHQSWRDSRLSY--NHTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQ 181

  Fly   139 KDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTPLVVD-ENIELP 202
            .|..|||.:::|..::|.|:.|.||.|.|||.|.:||..::::|:::.|......:.. :.::|.
Mouse   182 PDGVILYSIRITSTVACDMDLAKYPLDEQECMLDLESYGYSSEDIVYYWSENQEQIHGLDRLQLA 246

  Fly   203 QVALIRNE-TADCTQVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVSFWIKPEAAP 266
            |..:.... |.:.....|.|.|..|.:.|.|:|....|:..:|:|:.::|.||||||||...|.|
Mouse   247 QFTITSYRFTTELMNFKSAGQFPRLSLHFQLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVP 311

  Fly   267 ARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLIN---------- 321
            |||:||:|::||::|....::||||..|.:||:|.:..:|.||||.||:||...:
Mouse   312 ARVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKRK 376

  Fly   322 -----------------IVL---------SDTPIPKPMAYPPKPVAGD------GPKKEGEGAPP 354
                             |||         .:..|.:.....|..:.|.      ..|||| |:.|
Mouse   377 AKVKVTKPRAEMDVRNAIVLFSLSAAGVSQELAISRRQGRVPGNLMGSYRSVEVEAKKEG-GSRP 440

  Fly   355 GGSNSTASKQQATMLPLADEKIEKIEKIFDEMTKNRRIVTTTRRVVRPPLDADGPWIPRQESRII 419
            ||.....|:.:                                     |:|||
Mouse   441 GGPGGIRSRLK-------------------------------------PIDAD------------ 456

  Fly   420 LTPTIAPPPPPPQPAAPEPELPKPKLTPAQERLKRAIYIDRSSRVLFPALFASLNGIYWCVF 481
                                                 .||..:|.:|||.||::|.|||..:
Mouse   457 -------------------------------------TIDIYARAVFPAAFAAVNIIYWAAY 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:273305	139/508 (27%)
		Neur_chan_LBD	38..235	CDD:280998	62/198 (31%)
		Neur_chan_memb	243..>334	CDD:280999	43/126 (34%)
Gabrd	XP_006538609.2	LGIC_ECD	97..280	CDD:355788	59/184 (32%)
		Cys-loop	198..212	CDD:349787	7/13 (54%)
		LGIC_TM_GABAAR_delta	283..>371	CDD:349857	40/87 (46%)
		TM1 helix	286..306	CDD:349857	10/19 (53%)
		TM2 helix	315..336	CDD:349857	8/20 (40%)
		TM3 helix	346..368	CDD:349857	9/21 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810