Protein Alignment ort and Gabra1

DIOPT Version :10

• Sequence 1: NP_524406.1
• Gene: ort / 45910
• FlyBaseID: FBgn0003011
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: XP_006532258.1
• Gene: Gabra1 / 14394
• MGIID: 95613
• Length: 553
• Species: Mus musculus
• Alignment Length: 485
• Identity: 148/485 - (30%)
• Similarity: 237/485 - (48%)
• Gaps: 70/485 - (14%)

  Fly     8 LVICTICMKHY---AKGEFQQSLAI-TDILPEDIKRYD-KMRPPKKEGQPTIVYFHVTVMGLDSI 67
            |::.|:..:.|   ::.|.:.:..: |.||...:..|| ::||...| :.|.|...:.|.....:
Mouse   114 LILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGE-RVTEVKTDIFVTSFGPV 177

  Fly    68 DENSMTYVADVFFAQTWKDHRLRLPENMTQEYRLLEVDWL--KNMWRPDSFFKNAKSVTFQTMTI 130
            .::.|.|..||||.|:|||.||:....||    :|.::.|  ..:|.||:||.|.|......||:
Mouse   178 SDHDMEYTIDVFFRQSWKDERLKFKGPMT----VLRLNNLMASKIWTPDTFFHNGKKSVAHNMTM 238

  Fly   131 PNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQW--DPTTPL 193
            ||..:.:.:|.|:||.::||::..|.|:...:|.|...|.|:..|.::|..:::::|  :|...:
Mouse   239 PNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSV 303

  Fly   194 VV-DENIELPQVALIRNETADCTQVY-STGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWV 256
            || ::...|.|..|: .:|.|...|. |||.:..:...|.|||::.|:|..||:|..|.||:|.|
Mouse   304 VVAEDGSRLNQYDLL-GQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQV 367

  Fly   257 SFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLIN 321
            |||:..|:.|||...|||::||::|....:::|||.|:|..|:|.|::||..|||.||:|:..:|
Mouse   368 SFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVN 432

  Fly   322 IVLSDTPIPKPMAYPPKPVAGDGPKKEGEGAPPGGSNSTASKQQATMLPLADEKIEKIEKIFDEM 386
            .            :..:..|.||                     .:::|      ||.:|:.|.:
Mouse   433 Y------------FTKRGYAWDG---------------------KSVVP------EKPKKVKDPL 458

  Fly   387 TKNRRIVTTTRRVVRPPLDADGPWIPRQESRIILTPTIAPPPPPPQPAAPEPELPKPKLTPAQER 451
            .|.......|.....|.|....|.:    :.|..:.||     .|:...||.:.|:||.|
Mouse   459 IKKNNTYAPTATSYTPNLARGDPGL----ATIAKSATI-----EPKEVKPETKPPEPKKT----- 509

  Fly   452 LKRAIYIDRSSRVLFPALFASLNGIYWCVF 481
            ......|||.||:.||.||...|.:||..:
Mouse   510 FNSVSKIDRLSRIAFPLLFGIFNLVYWATY 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:455710	143/456 (31%)
		LGIC_ECD_HisCl	51..235	CDD:349793	60/189 (32%)
		Cys-loop	155..169	CDD:349793	4/13 (31%)
Gabra1	XP_006532258.1	LIC	105..539	CDD:455710	148/483 (31%)
		LGIC_ECD_GABAAR_A1	153..346	CDD:349835	63/198 (32%)
		Cys-loop	263..277	CDD:349835	4/13 (31%)