DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ort and gabrd

DIOPT Version :9

Sequence 1:	NP_524406.1	Gene:	ort / 45910	FlyBaseID:	FBgn0003011	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	XP_017951272.2	Gene:	gabrd / 100488161	XenbaseID:	XB-GENE-988598	Length:	450	Species:	Xenopus tropicalis

Alignment Length:	486	Identity:	148/486 - (30%)
Similarity:	227/486 - (46%)	Gaps:	89/486 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GEFQQS---LAITDILPEDIKRYDKMRPPKKEGQPTIVYFHVTVMGLDSIDENSMTYVADVFFAQ 82
            |||..|   ::....|.:.:|.|.:...|...|.|.||...|.|..:|.|.|.:|.|...||..|
Frog    27 GEFIGSNIEISWVPNLDDLMKGYARNFRPGIGGAPVIVAVDVEVTSIDHISEVNMEYTMTVFLHQ 91

  Fly    83 TWKDHRLRLPENMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTMTIPNHYMWLYKDKTILYMV 147
            :|:|.||..  |.|.:...|:..:::.:|.||:|..||||..|..:|:.|..:.|..|..|||..
Frog    92 SWRDERLSY--NHTNKTLGLDSRFVEKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSS 154

  Fly   148 KLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTPLVVDEN-----IELPQVAL- 206
            ::|..:||.|:...||.|.|||.|::||..::::|::::|....    ::|     |||.|..:
Frog   155 RITSTVSCDMDLTKYPMDEQECMLELESYGYSSEDILYRWSENQ----EKNHGLDKIELAQFTVT 215

  Fly   207 ----IRNETADCTQVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVSFWIKPEAAPA 267
                .:||..    :.|.|.|..|.:.|.|:|....|:..:|:|:.::|.||||||||...|.||
Frog   216 NYRFTKNEMI----LKSAGEFPRLSLHFHLRRNRGVYIIESYVPSILLVAMSWVSFWISQAAVPA 276

  Fly   268 RVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLINIVLSDTPIPKP 332
            ||:||:|::||::|....:::|||..|.:||:|.:..:|.||||.||:||...:
Frog   277 RVSLGITTVLTMTTLMVSARTSLPRASAVKALDVYFLICYVFVFAALVEYAFAH----------- 330

  Fly   333 MAYPPKPVAGDGPKKEGEGAPPGGSNSTASKQQA----TMLPLA----DEKIEKIEKIFDEMTKN 389
                   .:.|..|||.........|......:.    .:|.|:    |:.:..|.| ....|:|
Frog   331 -------YSADYIKKEKVKTKASKKNKQVQMNEGQYAIVLLSLSILGMDQSLTLINK-HHFATQN 387

  Fly   390 RRIVTTTRR----VVRPPLDADGPWIPRQESRIILTPTIAPPPPPPQPAAPEPELPKPKLTPAQE 450
            ...:...|:    :.|.|.       |.:|||:                       |..|.|.:
Frog   388 EARLEGMRKDKLQICRDPK-------PEKESRL-----------------------KSLLRPIE- 421

  Fly   451 RLKRAIYIDRSSRVLFPALFASLNGIYWCVF 481
                |..||..:|.:|||.||::|.|||..:
Frog   422 ----ADSIDVYARAVFPAAFAAVNIIYWVAY 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ort	NP_524406.1	LIC	31..481	CDD:273305	144/471 (31%)
		Neur_chan_LBD	38..235	CDD:280998	68/206 (33%)
		Neur_chan_memb	243..>334	CDD:280999	38/90 (42%)
gabrd	XP_017951272.2	LIC	42..448	CDD:273305	144/469 (31%)
gabrd	XP_017951272.2	LGIC_ECD	61..244	CDD:355788	64/192 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910