DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nec and SERPINH1

DIOPT Version :9

Sequence 1:	NP_524851.1	Gene:	nec / 45908	FlyBaseID:	FBgn0002930	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001193943.1	Gene:	SERPINH1 / 871	HGNCID:	1546	Length:	418	Species:	Homo sapiens

Alignment Length:	368	Identity:	84/368 - (22%)
Similarity:	160/368 - (43%)	Gaps:	22/368 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 LFKEIIKSQSQQNVVFSPFSVHALLALIYGASDGKTFRELQKAGEFSKNAMAVAQDFESVIKYKK 178
            |::.:.|.|:.:|::.||..|.:.|.|:  :..||.....|.....|...:...:....:.:..:
Human    54 LYQAMAKDQAVENILVSPVVVASSLGLV--SLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLR 116

  Fly   179 HLEGADLTLATKVYYNRELGGVNHSY-DEY---AKFYFSAGTEAVDMQNAKDTAAKINAWVMDTT 239
            .|..:.....|....:|..|..:.|: |::   :|.:::.....::.::.:.....||.|...||
Human   117 SLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTT 181

  Fly   240 RNKIRDLVTPTDVDPQTQALLVNAVYFQGRWEHEFATMDTSPYDFQHTNGRISKVAMMFNDDVYG 304
            ..|:.::.  .||:....||||||::|:..|:.:|.........|..|......|.||....:|.
Human   182 DGKLPEVT--KDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRTGLYN 244

  Fly   305 L--AELPELGATALELAYKDSATSMLILLPNETTGLGKMLQQLSRPEFDLNRVAHRLRRQSVAVR 367
            .  .|..:|....:.||:|  .:|::||:|:....|.::.:.|::.:  |.....::::::||:.
Human   245 YYDDEKEKLQIVEMPLAHK--LSSLIILMPHHVEPLERLEKLLTKEQ--LKIWMGKMQKKAVAIS 305

  Fly   368 LPKFQFEFEQDMTEPLKNLGVHQMFTPNSQVTKLMD--QPVRVSKILQKAYINVGEAGTEASAAS 430
            |||...|...|:.:.|..||:.:....|......|.  :.:.::.:.......:...|.......
Human   306 LPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFELDTDGNPFDQDI 370

  Fly   431 YAKFVPLSLPPKPTEFVANRPFVFAVR--TPASVLFIGHVEYP 471
            |.:....|    |..|.|:.||:|.||  ...|:||||.:..|
Human   371 YGREELRS----PKLFYADHPFIFLVRDTQSGSLLFIGRLVRP 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nec	NP_524851.1	SERPIN	108..468	CDD:238101	83/363 (23%)
SERPINH1	NP_001193943.1	serpinH1_CBP1	36..417	CDD:381003	84/368 (23%)
SERPINH1	NP_001193943.1	Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	415..418
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920