Protein Alignment nec and SERPING1

DIOPT Version :9

• Sequence 1: NP_524851.1
• Gene: nec / 45908
• FlyBaseID: FBgn0002930
• Length: 476
• Species: Drosophila melanogaster
• Sequence 2: NP_000053.2
• Gene: SERPING1 / 710
• HGNCID: 1228
• Length: 500
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 127/540 - (23%)
• Similarity: 224/540 - (41%)
• Gaps: 111/540 - (20%)

  Fly     1 MASKVSILLLLTVHLLAAQTFAQELIAWQRQQQQQQQQQLQLQQQLLLQQQQHQRNPRPELGLRS 65
            |||::::|.||.: |||....:....|.....|..:..|.:.:.::............|.|.:.|
Human     1 MASRLTLLTLLLL-LLAGDRASSNPNATSSSSQDPESLQDRGEGKVATTVISKMLFVEPILEVSS 64

  Fly    66 LPGNPWTQNNQEAISDVVAVDLTKR---EPVTPP---PNRP-----------PPVFSY------- 106
            ||....|.|:...|:.....:.|.:   ||.|.|   |.:|           |...|:
Human    65 LPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCPGPVTL 129

  Fly   107 ----------------MDRFSSELFKEI-IKSQSQQNVVFSPFSVHALLALIYGASDGKTFRELQ 154
                            :..||.:|:... ...:.:.|:.|||||:.:||..:           |.
Human   130 CSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQV-----------LL 183

  Fly   155 KAGEFSKNAMAVAQDFESVIKYKKH-------LEG---ADLTLATKVYYNRELGGVNHSYDEYAK 209
            .|||.:|.      :.||::.|.|.       |:|   ..:|..::::::.:| .:..::...::
Human   184 GAGENTKT------NLESILSYPKDFTCVHQALKGFTTKGVTSVSQIFHSPDL-AIRDTFVNASR 241

  Fly   210 FYFSAGTEAVDMQNAKDTAAKINAWVMDTTRNKIRDLV--TPTDVDPQTQALLVNAVYFQGRWEH 272
            ..:|:....:. .|:......||.||...|.|||..|:  .|:|    |:.:|:||:|...:|:.
Human   242 TLYSSSPRVLS-NNSDANLELINTWVAKNTNNKISRLLDSLPSD----TRLVLLNAIYLSAKWKT 301

  Fly   273 EFATMDT--SPYDFQHTNGRISKVAMMFNDDVYGLAELPELGATA----LELAYKDSATSMLILL 331
            .|....|  .|:.|:::   :.||.|| |...|.:|...:....|    |:|::.   .|::||:
Human   302 TFDPKKTRMEPFHFKNS---VIKVPMM-NSKKYPVAHFIDQTLKAKVGQLQLSHN---LSLVILV 359

  Fly   332 P-NETTGLGKMLQQLSRPEFDLNRVAHRL---RRQSVAVRLPKFQFEFEQDMTEPLKNLGVHQMF 392
            | |....|..|.|.||...|  ..:..:|   :.|...:.||:.:....|||...::.|.... |
Human   360 PQNLKHRLEDMEQALSPSVF--KAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFD-F 421

  Fly   393 TPNSQVTKLMDQP-VRVSKILQKAYINVGEAGTEASAASYAKFVPLSLPPKPTEFVANRPFVFAV 456
            :.:..:..|.:.| ::||.:..:..:.:.|.|.||:|||     .:|:......|...:||:|.:
Human   422 SYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAAS-----AISVARTLLVFEVQQPFLFVL 481

  Fly   457 -----RTPASVLFIGHVEYP 471
                 :.|   :|:|.|..|
Human   482 WDQQHKFP---VFMGRVYDP 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nec	NP_524851.1	SERPIN	108..468	CDD:238101	96/388 (25%)
SERPING1	NP_000053.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..43		3/22 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	65..118		12/52 (23%)
		7 X 4 AA tandem repeats of [QE]-P-T-[TQ]	85..119		8/33 (24%)
		C1_inh	145..495	CDD:239005	96/390 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010