DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nec and Serpina3i

DIOPT Version :9

Sequence 1:	NP_524851.1	Gene:	nec / 45908	FlyBaseID:	FBgn0002930	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_017170641.1	Gene:	Serpina3i / 628900	MGIID:	2182841	Length:	457	Species:	Mus musculus

Alignment Length:	450	Identity:	117/450 - (26%)
Similarity:	199/450 - (44%)	Gaps:	80/450 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 WQRQQQQQQQQQLQLQQQL--------LLQQQQHQRNPRPE-LGLRSLPGNPWTQNNQEAISDVV 83
            | |:||.::...|..:.||        .||:::......|. ||...:     |.....|:.: |
Mouse     3 W-REQQTRKAATLTTRSQLSQTLAAGSALQEKRVMAGVSPAVLGCPDV-----TLERNTAVHE-V 60

  Fly    84 AVDLTKREPVTPPPNRPPPVFSYMDRFSSELFKEIIKSQSQQNVVFSPFSVHALLALIYGASDGK 148
            ..::|..:.:|        |.|....|:..|:::::.....:||||||||:...|||:...:...
Mouse    61 QENITSGDSLT--------VASSNTDFAFSLYRKLVLKNPDENVVFSPFSIFTALALLSLGAKSN 117

  Fly   149 TFRELQKAGEFSKNAMAVAQDFESVIKYKKHL-----EGADLTLATKVYYNRELGGVNHSYDEYA 208
            |.:|:.:..:|:... ....|.....:|...|     :...::..:.::..:.| .:...:.|.|
Mouse   118 TLKEILEGLKFNLTE-TPEPDIHQGFRYLLDLLSQPGDQVQISTGSALFVEKHL-QILAEFKEKA 180

  Fly   209 KFYFSAGTEAVDMQNAKDTAAKINAWVMDTTRNKIRDLVTPTDVDPQTQALLVNAVYFQ------ 267
            :..:.|.....|..........||.:|.:.|:.||::|:  :|:|..|..:|||.:||:
Mouse   181 RALYQAEAFTADFLQPCQAKKLINDYVSNQTQGKIKELI--SDLDKSTLMVLVNYIYFKGGRGHC 243

  Fly   268 --------GRWEHEFATMDTSPYDFQHTNGRISKVAMM---------FNDDVYGLAELPELGATA 315
                    |:|:..|...||....|.....|..||.||         |.||        ||..:.
Mouse   244 LGVEREELGKWKMPFDPRDTFNSKFYLDEKRSVKVPMMKIEELTTPYFRDD--------ELSCSV 300

  Fly   316 LELAYKDSATSMLILLPNETTGLGKMLQQLS---RPEFDLNRVAHRLRRQSVA-VRLPKFQFEFE 376
            :||.|..:| |.|.:||::    ||| ||:.   .|| .|.:..:.|:...:: :.||||....:
Mouse   301 VELKYTGNA-SALFILPDQ----GKM-QQVETSLHPE-TLRKWKNSLKPSRISELHLPKFSISND 358

  Fly   377 QDMTEPLKNLGVHQMFTPN---SQVTKLMDQPVRVSKILQKAYINVGEAGTEASAASYAK 433
            ..:...|..||:.::|:..   |.:|..||  :|||:::.||.::|.|.||||:||:..|
Mouse   359 YSLEHVLPVLGIREVFSMQADLSAITGTMD--LRVSQVVHKAVLDVTETGTEAAAATGVK 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nec	NP_524851.1	SERPIN	108..468	CDD:238101	97/360 (27%)
Serpina3i	XP_017170641.1	serpinA3_A1AC	62..457	CDD:381019	101/383 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010