DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nec and Serpinb3a

DIOPT Version :9

Sequence 1:	NP_524851.1	Gene:	nec / 45908	FlyBaseID:	FBgn0002930	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_006249702.1	Gene:	Serpinb3a / 498209	RGDID:	1562868	Length:	387	Species:	Rattus norvegicus

Alignment Length:	400	Identity:	119/400 - (29%)
Similarity:	198/400 - (49%)	Gaps:	59/400 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 RFSSELFKEIIKSQSQQNVVFSPFSVHALLALIYGASDGKTFRELQKAGEFSKNA------MAVA 167
            :|:.||::::  ..|:.|:.:||.|:...||::...:.|.|.::::|..:|.:..      .|..
  Rat    10 QFTLELYRQL--RDSEDNIFYSPLSIMTALAMLQLGAKGNTEKQIEKVIQFHETTKKTTEKSADC 72

  Fly   168 QDFESV--------IKYKKHLEGADLTLATKVYYNRELGGVNH-----SYDEYAKFYFSAGTEAV 219
            .|.|||        .:..|..:..||..|..:|      |..|     ::.|..|.|:.|..|::
  Rat    73 HDEESVHEQFQKLMTQLNKSNDAYDLNSANSIY------GAKHFPFLQTFLEDIKEYYQANVESL 131

  Fly   220 DMQN-AKDTAAKINAWVMDTTRNKIRDLVTPTDVDPQTQALLVNAVYFQGRWEHEFATMDTSPYD 283
            |..: |:::..|||:||.:.|..||:||.....::..|..:|||||||:|:|.|:|        |
  Rat   132 DFAHAAEESEKKINSWVENQTNGKIKDLFPKGSLNSSTILVLVNAVYFKGQWNHKF--------D 188

  Fly   284 FQHT-------NGRISK-VAMMFNDDVYGLAELPELGATALELAYKDSATSMLILLPNETTGLGK 340
            .:||       |...|| |.||...:.:....|.::.|..:|:.||....||.||||.|..||.|
  Rat   189 EKHTEEDKFWLNKNTSKPVQMMRQKNEFNFIFLEDVQAKMVEIPYKGKELSMFILLPMEIDGLKK 253

  Fly   341 MLQQLSRPEFDLNRVAHRLRRQSVAVRLPKFQFEFEQDMTEPLKNLGVHQMFTPNSQVTKLMD-- 403
            :.:||:..:......|..:....:.:.||:|:.|.:.|:..||:::|:...|.     :|..|
  Rat   254 LEEQLTADKLLEWTRAENMNMIDLYLSLPRFKVEEKYDLPGPLQHMGMVDAFD-----SKKADFS 313

  Fly   404 -----QPVRVSKILQKAYINVGEAGTEASAASYAKFVPLSLPPKPTEFVANRPFVFAVRTPA--S 461
                 |.:.|||:|.|:::.|.|.||||:||:..: |.|:......:|..:.||:|.::..|  |
  Rat   314 GMSSTQGLMVSKVLHKSFVEVNEEGTEAAAATGVE-VSLTSAQITEDFNCDHPFLFLIKHNATNS 377

  Fly   462 VLFIGHVEYP 471
            :||.|.:..|
  Rat   378 ILFFGRMSSP 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nec	NP_524851.1	SERPIN	108..468	CDD:238101	118/395 (30%)
Serpinb3a	XP_006249702.1	SERPIN	5..387	CDD:294093	118/398 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730