DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nec and serpine2

DIOPT Version :9

Sequence 1:	NP_524851.1	Gene:	nec / 45908	FlyBaseID:	FBgn0002930	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_956478.1	Gene:	serpine2 / 393153	ZFINID:	ZDB-GENE-040426-848	Length:	395	Species:	Danio rerio

Alignment Length:	393	Identity:	119/393 - (30%)
Similarity:	190/393 - (48%)	Gaps:	48/393 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 SYMDRFSS---ELFKEIIKSQSQQNVVFSPFSVHALLALIYGASDGKTFRELQKAGEFSKNAMAV 166
            ||..|.|.   ::|.::::.::|:||:.||..|.::|.::...:.|.|.|:|....::.||.
Zfish    25 SYGARGSDLGLQVFMQVLQDRAQENVLLSPHGVASVLGMLLPGAHGDTRRQLLNGLKYKKNG--- 86

  Fly   167 AQDFESVIKYKKHL---EGADL-TLATKVYYNRELGGVNHSYDEYAKFYFSAGTE-------AVD 220
              .::.:.|..|.|   ..||: |:|..::.|.   |.:...|     :.||..|       :||
Zfish    87 --PYKMLRKLHKSLTTKSNADIVTIANALFPNE---GFSMKED-----FLSANRENFLCESHSVD 141

  Fly   221 MQNAKDTAAKINAWVMDTTRNKIRDLVTPTDVDPQ-TQALLVNAVYFQGRWEHEFATMDTSPYDF 284
            ..:.:..|..||.||.::|:.:|..:||....|.. |:.:.||:::|:|.|:..|....|.|..|
Zfish   142 YSDPEAAAQSINDWVKNSTKGQIPSVVTADMFDTALTRLVAVNSIFFKGLWKSRFQPQSTKPRSF 206

  Fly   285 QHTNGRISKVAMMFNDDVY--GLAELPELGA--TALELAYKDSATSMLILLPNE-TTGLGKMLQQ 344
            ...:|...||.||....|:  |.|..|: |.  ..:||.|..::.||.|.||.| :|.|..:|
Zfish   207 TAGDGNTYKVPMMSQLSVFNMGQASTPD-GQKYIVIELPYHGNSMSMFIALPTEDSTPLSSIL-- 268

  Fly   345 LSRPEFDLNRV---AHRLRRQSVAVRLPKFQFEFEQDMTEPLKNLGVHQMFTPN-SQVTKLMDQP 405
               |....|.:   ...:..:.:.:.:|||..|.|.|:..|||.||:..:|..| :....|..:.
Zfish   269 ---PHISTNTIQSWTKLMNPRRMRLLMPKFTVEQELDLETPLKALGIKDIFDQNKADFRHLSSES 330

  Fly   406 VRVSKILQKAYINVGEAGTEASAASYAKFVPLSLPPKPTEFVANRPFVFAVR--TPASVLFIGHV 468
            :.|||.||||.|.|.|.||:|||.:.......|.||..|   .:|||:|.:|  :..::||.|.:
Zfish   331 IYVSKALQKAKIEVNEDGTKASATTSVILHARSSPPWVT---VDRPFLFLIRHNSSGTILFAGQI 392

  Fly   469 EYP 471
            ..|
Zfish   393 NKP 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nec	NP_524851.1	SERPIN	108..468	CDD:238101	116/385 (30%)
serpine2	NP_956478.1	PAI-1_nexin-1	26..395	CDD:239006	117/390 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.030