DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nec and Serpina11

DIOPT Version :9

Sequence 1:	NP_524851.1	Gene:	nec / 45908	FlyBaseID:	FBgn0002930	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_955018.2	Gene:	Serpina11 / 380780	MGIID:	2685741	Length:	427	Species:	Mus musculus

Alignment Length:	405	Identity:	101/405 - (24%)
Similarity:	184/405 - (45%)	Gaps:	43/405 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 EPVTPPPNRPPPVF----SYMDRFSSELFKEIIKSQSQQNVVFSPFSVHALLALIYGASDGKTFR 151
            :|.:.....|.|.:    ..:..|:..|:|::.: :...|::|||.|:.:.|||:...:...|..
Mouse    39 QPASHQSLEPAPAYHKVTPTITNFALRLYKQLAE-EVAGNILFSPVSLSSSLALLSLGAHADTQT 102

  Fly   152 ELQKAGEFSKN---AMAVAQDFESVIKYKKHL-----EGADLTLATKVYYNRELGGVNHSYDEYA 208
            ::.::..|:..   |..|.:.|:|::    |.     ...:|.|...::.:|:|.......|. |
Mouse   103 QILESLGFNLTETPAADVHRGFQSLL----HTLDLPSPKLELKLGHFLFLDRQLKPQQRFLDS-A 162

  Fly   209 KFYFSAGTEAVDMQNAKDTAAKINAWVMDTTRNKIRDLVTPTDVDPQTQALLVNAVYFQGRWEHE 273
            |..:.|...:.:...|..|..:||..|...|..::...:.....|  |..:|:|.::|:.:.:|.
Mouse   163 KELYGALAFSANFTEAAATGQQINDLVRKQTYGQVVGCLPEFSHD--TLMVLLNYIFFKAKCKHP 225

  Fly   274 FATMDTSPYDFQHTNGRIS-KVAMMFNDDVYGLAELPELGATALELAYKDSATSMLILLPNETTG 337
            |....|...:....:.|.. ::.||...:::......|...|.|::.|..:|. :|::||:.
Mouse   226 FDRYQTRKQESFSLDQRTPLRIPMMRQKEMHRFLYDQEASCTVLQIEYSGTAL-LLLVLPDP--- 286

  Fly   338 LGKMLQQLS---RPEFDLNRVAHRLRRQSVAVRLPKFQFEFEQDMTEPLKNLGVHQMFTPNSQVT 399
             ||| ||:.   :|| .|.|...|.....:.:.||:|......::.|.|..:|:..:|...:.::
Mouse   287 -GKM-QQVEAALQPE-TLRRWGQRFLPSLLDLHLPRFSISATYNLEEILPLIGLGNLFDMEADLS 348

  Fly   400 KLMDQPVR-VSKILQKAYINVGEAGTEASAASYAKFVPLSLPPKPTEFVA-----NRPFVFAV-- 456
            .:|.|..: ||::..||.:::.|.||||:|||..    ||.||......|     ||||:..:
Mouse   349 GIMGQLNKTVSRVSHKAIVDMNEKGTEAAAASGL----LSQPPALNMTSAPQAHYNRPFLLLLWE 409

  Fly   457 RTPASVLFIGHVEYP 471
            .|..|:||:|.|..|
Mouse   410 VTTQSLLFLGKVVNP 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nec	NP_524851.1	SERPIN	108..468	CDD:238101	96/379 (25%)
Serpina11	NP_955018.2	SERPIN	58..421	CDD:294093	96/381 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100