DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nec and Spn28Dc

DIOPT Version :9

Sequence 1:	NP_524851.1	Gene:	nec / 45908	FlyBaseID:	FBgn0002930	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_609172.1	Gene:	Spn28Dc / 34091	FlyBaseID:	FBgn0031973	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	124/563 - (22%)
Similarity:	219/563 - (38%)	Gaps:	137/563 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLLTVHLLAAQTFAQEL-----IAW-----QRQQQQQQQQQLQLQQQLLLQQQQHQRNPRPELG 62
            |||::.....::.|..:|     :|:     ||:.|.||            :.|||.:...|.:.
  Fly     8 LLLVSSVCCESELFRDDLRTPETMAYINGLMQRRHQMQQ------------EAQQHIQAIPPAVP 60

  Fly    63 LRSLPG--NPWTQNNQEAISDVVAVDLTKREPVTPPPNRPPPVFS--YMD------------RFS 111
            |:| ||  |.....|..|::.:....:        .|:..|..:|  |:|            .|:
  Fly    61 LQS-PGLVNGLGNQNDPALNRISGTSV--------KPSNLPAAYSNGYVDLATSDRIANSVLNFA 116

  Fly   112 SELFKEIIKSQSQQNVVFSPFS-VHALLALIYGASDGKTFRELQKAGEFSKNAM------AVAQD 169
            :.|.:.:...::|   ::||.| ||:|..|:.||. |:::.||....:....:.      .:.||
  Fly   117 NILGQHLANGKTQ---IYSPLSIVHSLALLLLGAK-GRSYEELSTVFDIPDTSRLHEQFGLMLQD 177

  Fly   170 FESVIK-----------------------------YKKHLEGADLTLATKVYYNRELGGVNHSYD 205
            .:...:                             ::.||...   |.|:..|.     :|..|.
  Fly   178 LQQPTREAISAGRPLTDWRASSAMRSNRRAQRPGAHEVHLANG---LFTQTGYT-----LNPDYR 234

  Fly   206 EYAKFYFSAGTEAVDMQNAKDTAA-KINAWVMDTTRNKIRDLVTPTDVDPQTQALLVNAVYFQGR 269
            ......:::..:..|.:.:..||. .|||:|...|:|.|.:::. :|:...|:.:|.||:||:..
  Fly   235 RVIVEVYASDLQIQDFEGSPATARYNINAYVAQHTKNHIENIIA-SDIPQTTRMILANALYFKAF 298

  Fly   270 WEHEFATMDTSPYDFQHTNGR----ISKVAMMFNDDVYGLAELPELGATALELAYKDSATSMLIL 330
            ||.:|....|.|.:| :.||.    :.:|.||.....|...|..|||...:.|.|:.:.::|.|:
  Fly   299 WETDFIESATRPDNF-YPNGEGTEPVMRVQMMATGGAYPYHEDHELGCKIIGLPYRGNLSTMYII 362

  Fly   331 LPNETTGLGKMLQQLSRPEFDLNRVAHRLRRQSVAVRLPKFQFEFEQDMTEPLKNLGVHQMFTPN 395
            .|.:::....|..|.......:..:..|:.|::..|..||.......::...::.:|:..:|:..
  Fly   363 QPFKSSVRELMALQKRLTADKIESMISRMYRRAALVAFPKMHLTESVNLKTVMQRMGLGGIFSAV 427

  Fly   396 SQVTKLM--DQPVR----------------------------VSKILQKAYINVGEAGTEASAAS 430
            .....|:  ::..|                            |..|:.|....|.|.|||| |||
  Fly   428 QNDLSLIATNEATRTNALGGNSLQNLEAQRRAGTGGARSDLVVDDIVHKVDFTVNEQGTEA-AAS 491

  Fly   431 YAKFVPLSLPPKPTEFVANRPFVFAVRTPAS--VLFIGHVEYP 471
            ...::..|.|  ...|..:.||:..||...:  |||.|.:..|
  Fly   492 SVTYLKKSGP--DVLFRGDTPFMVLVRHDPTKLVLFYGLINEP 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nec	NP_524851.1	SERPIN	108..468	CDD:238101	97/444 (22%)
Spn28Dc	NP_609172.1	SERPIN	111..527	CDD:238101	95/432 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
	3	3.010