DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nec and serpinc1

DIOPT Version :9

Sequence 1:	NP_524851.1	Gene:	nec / 45908	FlyBaseID:	FBgn0002930	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_878283.1	Gene:	serpinc1 / 321545	ZFINID:	ZDB-GENE-030131-264	Length:	450	Species:	Danio rerio

Alignment Length:	440	Identity:	115/440 - (26%)
Similarity:	212/440 - (48%)	Gaps:	43/440 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 NPRPELGLRSLPGNPW-TQNNQEAISDVVAVDLTKREPVTPPPNRPPPVFSYM---DRFSSELFK 116
            |.:|    :.||..|. ...|.:.|.       ..:||...|....|.|:...   .||:..|||
Zfish    26 NAKP----KDLPLEPMCIYRNPDEIQ-------PNKEPENIPVGTNPRVWELSKANSRFALSLFK 79

  Fly   117 EIIKSQS-QQNVVFSPFSVHALLALIYGASDGKTFRELQKAGEF----SKNAMAVAQDFESV--- 173
            ::.:.:| .:|:..||.|:....|:....:...|..:|.|..:|    .|.:..|...|..:
Zfish    80 QLAEGKSNDENIFLSPISISTAFAMTKLGACNTTLEQLMKVFQFDTIKEKTSDQVHFFFAKLNCR 144

  Fly   174 IKYKKHLEGADLTLATKVYYNRELGGVNHSYDEYAKFYFSAGTEAVDMQNAKDTAAK--INAWVM 236
            :..||| |..:|..|.:::.::.. ..|.::...::..:.|....:|.:. |..|::  ||.|:.
Zfish   145 LYRKKH-ETTELISANRLFGDKST-TFNETFQHISETVYGAKLMPLDFKE-KPEASRITINEWIA 206

  Fly   237 DTTRNKIRDLVTPTDVDPQTQALLVNAVYFQGRWEHEFATMDTSPYDFQHTNGRISKVAMMFNDD 301
            :.|.|:|:|.:....:|..|..:||||:||:|:|:::|...:....||..:......|.||:.:.
Zfish   207 NKTENRIKDTLPEGSIDTNTILVLVNAIYFKGQWKNKFDKQNVMKLDFHVSPTHKCPVPMMYQEK 271

  Fly   302 VYGLAELPELGATALELAYKDSATSMLILLPNETTGLGKMLQQLSRPEFDLNRVA---HRLRRQS 363
            .:..|::||.....|||.|.....:|:::||.|...|.:::..:     :|.::.   |.::..:
Zfish   272 KFQYAKIPEDKVKILELPYNGGDITMVLILPIEGATLSEVVANM-----NLKKLVGWLHAMKETT 331

  Fly   364 VAVRLPKFQFEFEQDMTEPLKNLGVHQMFTP-NSQVTKLM---DQP-VRVSKILQKAYINVGEAG 423
            |||::|:|:.|....:.|.|..:|:..:|:| |:.:..::   :.| :.:|....||::.|.|.|
Zfish   332 VAVQIPRFRVEDSFSLKEQLTKMGLEDLFSPANASLPGMVADAEGPNLFISDAYHKAFLEVNEEG 396

  Fly   424 TEASAASYAKFVPLSLPPKPTEFVANRPFVFAVRTPA--SVLFIGHVEYP 471
            :|||||:.......||.....:|||:|||:..:|..:  :::|.|.|..|
Zfish   397 SEASAATAVVATGRSLNIFREQFVADRPFLLFIRESSINALIFTGRVANP 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nec	NP_524851.1	SERPIN	108..468	CDD:238101	101/379 (27%)
serpinc1	NP_878283.1	antithrombin-III_like	62..443	CDD:239000	102/388 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.890