DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nec and Serping1

DIOPT Version :9

Sequence 1:	NP_524851.1	Gene:	nec / 45908	FlyBaseID:	FBgn0002930	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_954524.1	Gene:	Serping1 / 295703	RGDID:	735225	Length:	504	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	133/556 - (23%)
Similarity:	220/556 - (39%)	Gaps:	139/556 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASKVSILLLLTVHLLAAQTFAQELIAWQRQQQQQQQQQLQLQQ--QLLLQQQQHQRNPRPELGL 63
            ||||::.|.||.:.|...:.|:...:.     ....|..|.:|:  :..:.::...|:|....|.
  Rat     1 MASKLTPLTLLLLLLAGDRAFSDSEVT-----SHSSQDPLVVQEGSRDSVPERDGSRSPIEHTGQ 60

  Fly    64 RSLPGNPW-TQNNQEAIS----DVVA---------------VDLTKREPV---TPP--------- 96
            .|    .| |.:....||    |.||               .|...:.||   :||
  Rat    61 SS----TWPTTSGSTKISNDTMDQVANESFIQHVQPAAQLPEDSPSQSPVNSSSPPSTASAPPTQ 121

  Fly    97 ----PNRPPPV--FSYMDRFSSE-LFKEII-------------KSQSQQNVVFSPFSVHALLA-L 140
                |..|.|:  .|..||.||| ...|.:             ..:::.|:.|||||:.:||. :
  Rat   122 APTEPLCPEPLAWCSDSDRDSSEATLSEALTDFSVKLYHAFSATKKAETNMAFSPFSIASLLTQV 186

  Fly   141 IYGASDGKTFRELQKAGEFSKNAMAVAQDFESVIKYKKHLEGADLTLATKVYYNRELG----GVN 201
            :.||.| .|...|:       :.::..:||..|.:..|......:|..::::::.:|.    .||
  Rat   187 LLGAGD-STKSNLE-------DILSYPKDFACVHQTLKAFSSKGVTSVSQIFHSPDLAIRDTYVN 243

  Fly   202 HSYDEYAKFYFSAGTEAVDMQNAKDTAAK-INAWVMDTTRNKIRDLV--TPTDVDPQTQALLVNA 263
            .|...|.......|.:.       |...| ||.||.:.|.:||.:|:  .|:|    |:.:|:||
  Rat   244 ASLSLYGSSPRVLGPDG-------DANLKLINTWVAENTNHKINELLDSLPSD----TRLVLLNA 297

  Fly   264 VYFQGRWEHEFATMDTSPYDFQHTNGRISKVAM---------MFNDDVYGLAELPELGATALELA 319
            ||...:|:..|....... .|.:.|..| ||.|         :|||...      :.....|:|:
  Rat   298 VYLSAKWKKTFEQKKMMA-SFLYKNSMI-KVPMLSSKKYPLALFNDQTL------KAKVGQLQLS 354

  Fly   320 YKDSATSMLILLPNETTGLGKMLQQLSRPEFDLNRVAHR--LRR------QSVAVRLPKFQFEFE 376
            :.   .|.:|::|...|      .||...|..||....:  |::      |...|.:|:.:.:..
  Rat   355 HN---LSFVIMVPQSPT------HQLEDMEKALNPTVFKAILKKLELSKFQPTYVMMPRIKVKSS 410

  Fly   377 QDMTEPLKNLGVHQMFTPNSQVTKLMDQP-VRVSKILQKAYINVGEAGTEASAASYAKFVPLSLP 440
            |||...::.|.... ||.:..:..|.:.| ::||.:..:..:.:.|.|.||:|||     .:|:.
  Rat   411 QDMLSIMEKLEFFD-FTYDLNLCGLTEDPDLQVSSMKHETVLELTETGVEAAAAS-----TISVA 469

  Fly   441 PKPTEFVANRPFVFAV-----RTPASVLFIGHVEYP 471
            .....|...:||:|.:     :.|   :|:|.|..|
  Rat   470 RNLLIFEVQQPFLFLLWDQRHKFP---VFMGRVYDP 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nec	NP_524851.1	SERPIN	108..468	CDD:238101	99/404 (25%)
Serping1	NP_954524.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..75		10/60 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..132		7/37 (19%)
		SERPIN	150..499	CDD:294093	93/393 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100