DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nec and Serpinb1a

DIOPT Version :9

Sequence 1:	NP_524851.1	Gene:	nec / 45908	FlyBaseID:	FBgn0002930	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001026812.1	Gene:	Serpinb1a / 291091	RGDID:	1306203	Length:	379	Species:	Rattus norvegicus

Alignment Length:	381	Identity:	125/381 - (32%)
Similarity:	193/381 - (50%)	Gaps:	31/381 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 FSSELFKEIIKSQSQQNVVFSPFSVHALLALIYGASDGKTFRELQKAGEFSKNAMAVAQDFESV- 173
            |:.|||..:.:|....|:.|||||:.:.||:::..:.|.|..:|.|...|. :...|...|:|:
  Rat    11 FALELFHTLSESSPTGNIFFSPFSISSALAMVFLGTKGTTAAQLSKTFHFD-SVEDVHSRFQSLN 74

  Fly   174 IKYKKHLEGADLTLATKVYYNRELGGVNHSYDEYAKFYFSAGTEAVDMQNAKDTAAK-INAWVMD 237
            .:..|......|.||.::|..:....:........|.| .|....||.|:|.:.|.| ||.||..
  Rat    75 AEVSKRGASHTLKLANRLYGEKTYNFLPEFLTSTQKMY-GADLAPVDFQHASEDARKEINQWVKG 138

  Fly   238 TTRNKIRDLVTPTDVDPQTQALLVNAVYFQGRWEHEFATMDTSPYDFQHTNGRISKVAMMFNDDV 302
            .|..||.:|:....||..|:.:||||:||:|.||.:|...||:...|:........|.||:....
  Rat   139 QTEGKIPELLAVGVVDSMTKLVLVNAIYFKGMWEEKFMKQDTTDAPFRLNKKNTKSVKMMYQKKK 203

  Fly   303 YGLAELPELGATALELAYKDSATSMLILLP----NETTGLGKMLQQLSRPEFDLNRVAHRLRRQS 363
            :....:.:|....||:.|:....||:||||    :|:|||.|:.:|::     |.::....:|::
  Rat   204 FFFGYISDLKCKVLEMPYQGGELSMVILLPEDIEDESTGLKKIEEQIT-----LEKLREWTKREN 263

  Fly   364 -----VAVRLPKFQFEFEQDMTEPLKNLGVHQMFTPNSQVTKLM----DQPVRVSKILQKAYINV 419
                 |.|:||:|:.|....:...|..||:..:|  ||....|.    .:.:.:|||:.||::.|
  Rat   264 LENIDVHVKLPRFKIEESYILNSNLGRLGLQDLF--NSSKADLSGMSGSRDLFISKIVHKAFVEV 326

  Fly   420 GEAGTEASAAS--YAKFVPLSLPPKPTEFVANRPFVFAVR--TPASVLFIGHVEYP 471
            .|.||||:||:  .|.|..| ||.:  ||.|:.||:|.:|  ..|:|||:|.|..|
  Rat   327 NEEGTEAAAATAGIATFCML-LPEE--EFTADHPFIFFIRHNPTANVLFLGRVCSP 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nec	NP_524851.1	SERPIN	108..468	CDD:238101	123/376 (33%)
Serpinb1a	NP_001026812.1	SERPIN	4..379	CDD:294093	124/379 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.830