Protein Alignment nec and SERPINB1

DIOPT Version :10

• Sequence 1: NP_524851.1
• Gene: nec / 45908
• FlyBaseID: FBgn0002930
• Length: 476
• Species: Drosophila melanogaster
• Sequence 2: NP_109591.1
• Gene: SERPINB1 / 1992
• HGNCID: 3311
• Length: 379
• Species: Homo sapiens
• Alignment Length: 392
• Identity: 120/392 - (30%)
• Similarity: 194/392 - (49%)
• Gaps: 51/392 - (13%)

  Fly   109 RFSSELFKEIIKSQSQQNVVFSPFSVHALLALIYGASDGKTFRELQKAGEFSKNAMAVAQDFESV 173
            ||:.:||..:.::....|:..||||:.:.:|:::..:.|.|..:|.|...|: ....|...|:|
Human    10 RFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHFN-TVEEVHSRFQS- 72

  Fly   174 IKYKKHLEGAD--LTLATKVYYNRELGGVNHSYDEYAKFY------FSAGTEAVDMQNAKDTAAK 230
            :....:..||.  |.||.::|..:       :|:...:|.      :.|...:||.|:|.:.|.|
Human    73 LNADINKRGASYILKLANRLYGEK-------TYNFLPEFLVSTQKTYGADLASVDFQHASEDARK 130

  Fly   231 -INAWVMDTTRNKIRDLVTPTDVDPQTQALLVNAVYFQGRWEHEFATMDTSPYDFQHTNGRISKV 294
             ||.||...|..||.:|:....||..|:.:||||:||:|.|:.:|....|:...|:........|
Human   131 TINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTV 195

  Fly   295 AMMFNDDVYGLAELPELGATALELAYKDSATSMLILLP----NETTGLGKMLQQL--------SR 347
            .||:....:....:.:|....|||.|:....||:||||    :|:|||.|:.:||        ::
Human   196 KMMYQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEWTK 260

  Fly   348 PEFDLNRVAHRLRRQSVAVRLPKFQFEFEQDMTEPLKNLGVHQMFTPNSQVTKLMD----QPVRV 408
            || :|:.:       .|.|.||:|:.|....:...|..|||..:|  ||....|..    :.:.:
Human   261 PE-NLDFI-------EVNVSLPRFKLEESYTLNSDLARLGVQDLF--NSSKADLSGMSGARDIFI 315

  Fly   409 SKILQKAYINVGEAGTEASAAS--YAKFVPLSLPPKPTEFVANRPFVFAVR--TPASVLFIGHVE 469
            |||:.|:::.|.|.||||:||:  .|.|..| :|.:  .|.|:.||:|.:|  :..|:||:|...
Human   316 SKIVHKSFVEVNEEGTEAAAATAGIATFCML-MPEE--NFTADHPFLFFIRHNSSGSILFLGRFS 377

  Fly   470 YP 471
            .|
Human   378 SP 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nec	NP_524851.1	serpin42Dd-like_insects	105..471	CDD:381070	119/390 (31%)
SERPINB1	NP_109591.1	serpinB1_LEI	1..379	CDD:381028	119/390 (31%)
		CARD-binding motif (CBM). /evidence=ECO:0000269|PubMed:30692621	351..379		10/27 (37%)