DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nec and Serpind1

DIOPT Version :9

Sequence 1:	NP_524851.1	Gene:	nec / 45908	FlyBaseID:	FBgn0002930	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001317976.1	Gene:	Serpind1 / 15160	MGIID:	96051	Length:	478	Species:	Mus musculus

Alignment Length:	396	Identity:	101/396 - (25%)
Similarity:	184/396 - (46%)	Gaps:	64/396 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 RFSSELFKEIIKSQ--SQQNVVFSPFSVHALLALIYGASDGKTFRELQKAGEFSKNAMAVAQDFE 171
            :|:..|:: ::|.|  :..|:..:|..:...:.:|.....|:|..|:                 .
Mouse   111 KFAFNLYR-VLKDQATTSDNLFIAPVGISTAMGMISLGLRGETHEEV-----------------H 157

  Fly   172 SVIKYKKHLEGADLTLATKVY----------YNRELG----GVNHSYDE------------YAKF 210
            ||:.::..:..:.....|.::          :.|..|    .||..|.:            ..:|
Mouse   158 SVLHFRDFVNASSKYEVTTIHNLFRKLTHRLFRRNFGYTLRSVNGLYIQKQFPIREDFKAAMREF 222

  Fly   211 YFSAGTEAVDMQNAKDTA--AKINAWVMDTTRNKIRDLVTPTDVDPQTQALLVNAVYFQGRWEHE 273
            ||:...||    |..|.|  :|.|..::..|:..|::.:  .::||.||.|::|.:||:|.|.::
Mouse   223 YFAEAQEA----NFPDPAFISKANNHILKLTKGLIKEAL--ENIDPATQMLILNCIYFKGTWVNK 281

  Fly   274 FATMDTSPYDFQHTNGRISKVAMMFNDDVYGLAELPELGATALELAYKDSATSMLILLPNETTGL 338
            |....|..::|:.....:.||:||.....:..|...||....|:|.|. ...||||::|.:.:|:
Mouse   282 FPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYV-GGISMLIVVPRKLSGM 345

  Fly   339 GKMLQQLSRPEFDLNRVAHRLRRQSVAVRLPKFQFEFEQDMTEPLKNLGVHQMFTPNSQVTKLMD 403
            ..:..||: |:. :.|....:..::..|.||||:.|...::.|.||::|:.::|..|..::.:.|
Mouse   346 KTLEAQLT-PQV-VERWQKSMTNRTREVLLPKFKLEKNYNLVEVLKSMGITKLFNKNGNMSGISD 408

  Fly   404 QPVRVSKILQKAYINVGEAGTEASAASYAKFVPLSLPPKPTEFVANRPFVFAV---RTPASVLFI 465
            |.:.:.....::.|.|.|.||:|:|.:...|:|||   ....|..:|||:|.|   || :.:||:
Mouse   409 QRIAIDLFKHQSTITVNEEGTQAAAVTTVGFMPLS---TQVRFTVDRPFLFLVYEHRT-SCLLFM 469

  Fly   466 GHVEYP 471
            |.|..|
Mouse   470 GKVTNP 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nec	NP_524851.1	SERPIN	108..468	CDD:238101	99/391 (25%)
Serpind1	NP_001317976.1	HCII	43..476	CDD:239002	101/396 (26%)
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	54..78
		Glycosaminoglycan-binding site. /evidence=ECO:0000250	171..191		1/19 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020